More than 160 Cuban doctors and nurses arrived in Sierra Leone on Oct 2, 2014, to support local teams in controlling the Ebola epidemic. 300 more are being trained in Cuba at present and will be on their way to Liberia and Guinea in the coming weeks. The worldwide response to the Ebola epidemic has been slow and small. More nurses and doctors are certainly needed, not only from Cuba, but also f...

Ebola hemorrhagic fever is a potent infectious disease by Ebola virus caused 90% mortality rate. Ebola virus was first isolated in 1976 by, for single-stranded negative segment, non-segmented, enveloped RNA viruses belonging to filamentous virus family. Ebola virus can be divided into five different subtypes. Vaccination is the most conventional and effective prevention and infection control me...

http://www.cdc.gov/ncidod/EID/vol9no3/02-0208-app.htm[7/26/2010 4:55:29 PM] Appendix: Important Anthroponoses, Zoonoses, and Sapronoses1 Anthroponoses Measles*; rubella; mumps; influenza; common cold; viral hepatitis; poliomyelitis; AIDS*; infectious mononucleosis; herpes simplex; smallpox; trachoma; chlamydial pneumonia and cardiovascular disease*; mycoplasmal infections*; typhoid fever; chole...

Ebola zoonotic RNA filovirus represents human most virulent and lethal pathogens, which induces acute hemorrhagic fever and death within few days in a range of 60-90% of symptomatic individuals. Last outbreak in 2014 in West Africa caused panic that Ebola epidemic can be spread to other continents. Number of deaths in late December reached almost 8,000 individuals out of more than 20,000 sympto...

dear editor-in-chief the present global consideration is on the recent outbreak of 2014 western ebola virus in west africa (1 – 3). this viral hemorrhagic fever wide spreads to several countries in west africa and remote countries (1 - 3). with high death rate, the disease is presently on the list of public health threatens. the main problem for management of the infection is the limited knowl...

We previously developed optimized DNA vaccines against both Lassa fever and Ebola hemorrhagic fever viruses and demonstrated that they were protective individually in guinea pig and nonhuman primate models. In this study, we vaccinated groups of strain 13 guinea pigs two times, four weeks apart with 50 µg of each DNA vaccine or a mock vaccine at discrete sites by intradermal electroporation. Fi...

Ebola virus causes sporadic outbreaks of lethal hemorrhagic fever in humans, but there is no currently approved therapy. Cells take up Ebola virus by macropinocytosis, followed by trafficking through endosomal vesicles. However, few factors controlling endosomal virus movement are known. Here we find that Ebola virus entry into host cells requires the endosomal calcium channels called two-pore ...

Ebola virus infection causes hemorrhagic fever with high mortality rates in humans and nonhuman primates. Currently, there are no vaccines or therapies approved for human use. Outbreaks of Ebola virus have been infrequent, largely confined to remote locations in Africa and quarantine of sick patients has been effective in controlling epidemics. In the past, this small global market has generate...