BACKGROUND Alveolar echinococcosis (AE) is a chronic, rare and sometimes lethal parasitic infection in humans, caused by the larval stage of the fox tapeworm Echinococcus multilocularis. This study aimed to investigate the clinical aspects and treatment outcomes of patients with alveolar hydatid disease. METHODS The medical records of patients with alveolar echinococcosis admitted between 199...

Echinococcus spp. are cestode parasites commonly known as small tapeworms of carnivorous animals. Their medical importance lies in the infection of humans by the larval stage of the parasites, predominantly including Echinococcus granulosus, which is the causative agent of cystic echinococcosis (CE) and Echinococcus multilocularis, which causes alveolar echinococcosis (AE). A few other species ...

This book is a collection of short articles written by the participants of a research workshop held in Poznan, Poland, in September 2000. The workshop, supported by NATO Scientific Affairs, focused on the three major larval cestode diseases of humans: Taenia solium neurocysticercosis, Echinococcus granulosus cystic hydatidosis, and E. multilocularis alveolar hydatidosis. The format and depth of...

BACKGROUND Alveolar echinococcosis, caused by Echinococcus multilocularis larvae, is a chronic disease associated with considerable modulation of the host immune response. Dendritic cells (DC) are key effectors in shaping the immune response and among the first cells encountered by the parasite during an infection. Although it is assumed that E.multilocularis, by excretory/secretory (E/S)-produ...

background: alveolar echinococcosis (ae) is a chronic, rare and sometimes lethal parasitic infection in humans, caused by the larval stage of the fox tapeworm echinococcus multilocularis. this study aimed to investigate the clinical aspects and treatment outcomes of patients with alveolar hydatid disease. methods: the medical records of patients with alveolar echinococcosis admitted between 199...

This book is a collection of short articles written by the participants of a research workshop held in Poznan, Poland, in September 2000. The workshop, supported by NATO Scientific Affairs, focused on the three major larval cestode diseases of humans: Taenia solium neurocysticercosis, Echinococcus granulosus cystic hydatidosis, and E. multilocularis alveolar hydatidosis. The format and depth of...

OBJECTIVE This study is to clone and identify B- and T-cell combined epitopes from Em95 antigen. METHODS The B- and T-cell combined epitopes were predicted using bioinformatic software. Two DNA sequences of Em95-1 (which contained the coding region of one B- and T-cell combined epitope) and Em95-2 (which contained the coding regions of two B- and T-cell combined epitopes) were amplified by PC...

To the Editor: Alveolar echinococcosis, which is caused by the fox tapeworm Echinococcus multilocularis, is an emerging disease in Europe that shows a high mortality rate (1). Humans can become infected after ingesting parasite eggs (e.g., through direct contact with dogs and red foxes [Vulpes vulpes] or with their contaminated feces). E. multilocularis tapeworm eggs are extremely resistant and...

Abstract Alveolar echinococcosis (AE) is caused by the larval stage of Echinococcus multilocularis . Chemotherapy for AE involves albendazole (ABZ), which has shown insufficient efficacy. More effective chemotherapy needed. Previously, we have demonstrated that atovaquone (ATV), an antimalarial, inhibits mitochondrial complex III E and restricts development cysts in vivo experiments. Therefore,...