We herein present a patient with delayed-type allergic hypersensitivity against prilocaine leading to spreading eczematous dermatitis after subcutaneous injections for local anesthesia with prilocaine. Prilocaine allergy was proven by positive skin testing and subcutaneous provocation, whereas the evaluation of other local anesthetics - among them lidocaine, articaine and mepivacaine - did not ...

Allergic contact dermatitis is an immune-mediated antigen-specific skin reaction to an allergenic chemical that corresponds to a delayed-type hypersensitivity response (type IV reaction). Allergic contact dermatitis should be suspected when skin lesions are localized to the site of previous applications of the culprit drug. Lesions appear after re-exposure in susceptible persons, with delayed o...

Dupilumab, a therapeutic antibody that blocks the eczematous type 2 immune response in atopic dermatitis (AD), has shown efficacy many clinical trials and real-life observational studies. Besides blepharitis conjunctivitis, de novo appearance of head-neck is recognized as distinct side effect, occurring up to 10% patients at any time after dupilumab initiation. Histopathological features from c...

Results: On average, the etiological diagnosis was established 11 months after the onset of erythroderma. The underlying causes observed included immunodeficiency (30%), simple or complex ichthyosis (24%), Netherton syndrome (18%), and eczematous or papulosquamous dermatitis (20%). Five patients (10%) had erythroderma of unknown origin. The following parameters were of value in determining the ...

Atopic dermatitis is an inflammation of the skin, characterized by intense itchiness and dryness of the skin. A rash, flaking and lichenization of the skin are the common characteristics of subjects affected by this disease. The diagnosis is essentially clinical. It is a chronic condition which frequently becomes acute to the extent that we can distinguish between acute and chronic phases. The ...

BACKGROUND Allergic contact dermatitis (ACD) is a common and often challenging clinical problem. In vivo near-infrared confocal reflectance microscopy (CM) is a new vital microscopy technique. OBJECTIVE CM was used to evaluate acute ACD. METHODS Patch testing by means of Finn Chambers technique was performed in 5 subjects to induce an acute allergic skin reaction. Noninvasive CM images from...

A role of neurogenic inflammation induced by the neuropeptides and nerve growth factor (NGF) has been attributed to the pathogenesis of several cutaneous disorders such as psoriasis, wound healing and eczematous dermatitis. The underlying mechanisms of the inflammatory process induced by NGF are not clearly established. This study explored whether NGF influences the inflammatory process by indu...

Atopic dermatitis (AD) is a commonly recurring inflammatory eczematous condition of the skin which affects up to 2.4% global population and among them, 15-20% children 1-3% adults are affected globally. A 48 years old female patient diagnosed with AD, suffering from complaints pruritic lesions sticky pus collection on both arm abdominal region for last 36 months. The was treated modern medicine...

N ickel is a potentially allergenic material. It is one of the most common causes of allergic contact dermatitis, particularly in women. l-5 Nickel can also be considered an occupational allergen. Nickel contact dermatitis is common among industrial workers, especially in those industries that use nickel as a raw material. It has been demonstrated that U.S. S-cent coins contain approximately 25...