raspberry waste, obtained from two cultivars, meeker (erm) and willamette (erw) was subjected to evaluation antioxidants and antitumour activities as a potential source of phenolics. some phenolic acids and flavonoids were identified and quantified by hplc. antioxidant activity was tested by measuring ability to scavenge dpph• and •oh by esr spectroscopy. ic50dpph• varied from 0.67 for erm to 0...

A novel binary compounds as 3-(1,3-diphenyl-1H-pyrazol-4-yl)-2-phenyl-2H-benzo[f]indazole-4,9-dione (10) and fused 2-hydroxy-3-(4-hydroxy-7-methoxy-2-oxo-1,2-dihydroquinolin-3-yl)naphthalene-1,4-dione (7) naphtho[2,3-b]furan-3,4,9(2H)-trione (6) based on lawsone ‘that plays important precursor’ was synthesized by reaction with 1,3-diphenyl-1H-pyrazole-4-carbaldehyde halo-compounds, such 2-chlor...

The present study aimed to synthesize new metal complexes of diacetylmonoxime-N(4)antipyrinylthiosemicarbazone ligand and evaluate their antitumor activity. New with ferric, cobalt, nickel copper ions were prepared. Elemental, 1H Nuclear magnetic resonance, Mass spectroscopy, Electron paramagnetic Fourier Transform Infrared Spectroscopy, Ultraviolet–visible thermal gravimetric analysis used cha...

Introduction and Aim: Constant efforts are exerted to explore unique bioactive principles from natural sources that possess more effective specific antineoplastic activities. In the present study, we aimed evaluate antitumor activity of stem bark extract Oroxylum indicum in mice bearing Ehrlich ascites carcinoma (EAC). Materials Methods: Ninety female Swiss albino were categorized into fifteen ...

Anl i-tumor sera are now being extensively used in investigations of the activities of neoplasms (e.g. 4-7, 9-13, 15). I t is already known (7), concerning their effects on the biochemical activities of tumors, that Ehrlich ascites carcinoma cells, treated with their antisera in the presence of comp]ement, lose their capacity to respire in the presence of glucose but not in the presence of succ...

1-Methyl-3-nitro-l-nitrosoguanidine (nitrosoguanidine) was tested for activity against leukemia L1~10 (ascites and solid), Sarcoma 180 (ascites and solid), Ehrlich carcinoma (ascites and solid), 6CSHED ascites lymphosarcoma, and Mecca ascites lymphosarcoma in mice. Nitrosoguanidine was active against all the ascites tumors cxcept Mecca; it was inactive against the three solid tumors. When used ...

phenyl phenanthridinium bromide) has been shown to inhibit completely the incorporation of preformed purines into the nucleic acids of Ehrlich ascites carcinoma cells, but the drug does not ap preciably inhibit the incorporation of radioactive glycine into nucleic acids or proteins (4). These studies have been interpreted in terms of disrup tion of the normal relationship between intracellu lar...

It is becoming obvious that all cancers have a defective p53 pathway, either through TP53 mutation or deregulation of the tumor suppressor function of the wild type TP53. In this study we examined the expression of P53 and Caspase 3 in transperitoneally injected Ehrlich Ascites carcinoma cells (EAC) treated with Tetrodotoxin in the liver of adult mice in order to evaluate the possible pro apopt...

ETHNOPHARMACOLOGICAL RELEVANCE The plant Cleome gynandra L. (Capparidaceae), is commonly known as 'Hurhur'and 'Karaila' in India and 'Cat's whiskers' in English. Traditionally the whole plant is used in the treatment of tumor, anti-inflammatory and lysosomal stability actions. AIM OF STUDY The objective of present study is to explore the anticancer activity of the methanol extract of the Cleo...