CVD 103-HgR is a live oral cholera vaccine strain constructed by deleting 94% of the gene for the enzymatically active A subunit of cholera toxin from classical Inaba Vibrio cholerae O1 569B; the strain also contains a mercury resistance gene as an identifying marker. This vaccine was well tolerated and immunogenic in double-blind, controlled studies and was protective in open-label studies of ...

Vibrio cholerae is a gram-negative bacterium that is the causative agent of cholera, a severe diarrheal illness. The two biotypes of V. cholerae O1 capable of causing cholera, classical and El Tor, require different in vitro growth conditions for induction of virulence gene expression. Growth under the inducing conditions or infection of a host initiates a complex regulatory cascade that result...

The least common subsumer (lcs) w.r.t general EL-TBoxes does not need to exists in general due to cyclic axioms. In this report we present an algorithm for computing role-depth bounded EL-lcs based on the completion algorithm for EL. We extend this computation algorithm to a recently introduced probabilistic variant of EL: Prob-EL.

The least common subsumer (lcs) w.r.t general EL-TBoxes does not need to exists in general due to cyclic axioms. In this paper we present an algorithm for computing role-depth bounded EL-lcs based on the completion algorithm for EL. We extend this computation algorithm to a recently introduced probabilistic variant of EL: Prob-EL.

INTRODUCTION................................................................................. 72 GEOGRAPHY AND PATHOGENICITY............................................................... 72 TAXONOMY..................................................................................... 73 BIOCHEMICAL PROPERTIES...................................................................... 73 ANTIGENS AND ...

BACKGROUND—Although cholera has been present in Latin America since 1991, it had not been epidemic in Haiti for at least 100 years. Recently, however, there has been a severe outbreak of cholera in Haiti. METHODS—We used third-generation single-molecule real-time DNA sequencing to determine the genome sequences of 2 clinical Vibrio cholerae isolates from the current outbreak in Haiti, 1 strain ...

Outbreak of cholera still remains major public health problem in most of the developing countries including Nepal. A prospective study was carried out at Dhulikhel Hospital, Kathmandu University Teaching Hospital, Kavrepalanchok during 1st May 2004 to 31st October 2004. A total of 148 stool samples from patients with acute diarrhea were collected and further investigated for cholera. The study ...

To the Editor: The excellent article on measures for controlling plague in Alghero, Sardinia, describes the procedures introduced by the Calabrian doctor Quinto Tiberio Angelerio (1532–1617) to combat an outbreak during 1582–1583 (1). The authors cite 2 works published by Angelerio relating to these events, Ectypa (1588) (2) and Epidemiologìa (1598) (3). To say that Epidemiologìa was written on...