STUDY QUESTION Is it possible to extend the use of the 3-year one-rod etonogestrel (ENG)-releasing subdermal contraceptive implant to 5 years? SUMMARY ANSWER The extended use of the one-rod ENG-releasing subdermal contraceptive implant showed 100% efficacy in years 4 and 5. WHAT IS KNOWN ALREADY The initial regulated trials on the ENG-releasing subdermal contraceptive implant conducted in t...

Ch?ng (Chang) and ?n (Eng) Bunker were conjoined twins [2] in the nineteenth century in the United States, the first pair of conjoined twins [2] whose condition was well documented in medical records. Conjoined twins are a rare condition in which two infants are born physically connected to each other. In their youth, the brothers earned money by putting themselves on display as curiosities and...

RI HE death of Coloniel Ihliomiias Sinclair, C.1B., M.D., F.R.C.S.(Eng.), sometime Professor of Surgery in the Queen's University of Belfast, at the age of 82, terminates a career of outstanding distinictioni in the professionl of medicine. He belonge(d to a well-known and highly respectedl family, closely connectedl with the industrial and charitable life ol the citN-. He was ullllnarried an(l...

Hereditary hemorrhagic telangiectasia (HHT) is a vascular disease characterized by multiple focal telangiectases and arteriovenous malformations (AVMs) in the pulmonary, hepatic, and cerebral microcirculations. These fragile structures are low-pressure conduits that can affect local tissue blood flow, and their potential rupture in vital organs can lead to internal hemorrhage, anemia, and death...

This paper presents a framework aimed at supporting the decision-making process for the preliminary design of system architectures for the extraction of spatially and temporally distributed resources. The goal of the research is to provide a tool to identify “global best” architectures for resource extraction “systems of systems,” which usually differ from the sum of “local best” systems. The f...