In this study, we present results obtained on the diastereo- and enantioseparation of some basic natural synthetic Cinchona alkaloid analogs by applying liquid chromatographic (LC) subcritical fluid (SFC) modalities amylose cellulose tris-(phenylcarbamate)-based stationary phases using n-hexane/alcohol/DEA or CO2/alcohol/DEA mobile phase systems. Seven chiral in their immobilized form were empl...

Abstract A new synthesis strategy for the preparation of cellulose derivative-based chiral selectors and subsequent mild immobilization onto pre-functionalized silica gel are introduced, utilizing Cu(I)-catalyzed alkyne-azide Huisgen cycloaddition (“ click ”) chemistry. 3,5-dimethylphenyl carbamate derivative carrying propynyl groups was prepared by a combination carbonate aminolysis isocyanate...

A common approach in resolving enantiomers of chiral basic drugs by capillary electrophoresis (CE) is to use cyclodextrins (especially their anionic derivatives) as chiral selector in the acidic buffer (pH ≤ 3) in normal or reversed (carrier) mode. Then, some organic modifiers are added to the buffer solution if the resolution is not satisfactory. In case of cetirizine (CTN), applying the same ...

The enantioseparation of syn- and anti-3,5-disubstituted hydantoins 5a–i was investigated on three immobilized polysaccharide-based columns (CHIRAL ART Amylose-SA, CHIRAL Cellulose-SB, Cellulose-SC) by high performance liquid chromatography (HPLC) using n-hexane/2-PrOH (90/10, v/v) or 100% dimethyl carbonate (DMC) as mobile phases, respectively, supercritical fluid (SFC) CO2/alcohol (MeOH, EtOH...

Cyclodextrin (CD) derivatives are the most efficient and frequently used chiral selectors (CSs) in capillary electrophoresis (CE). There situations when use of a single CD as CS is not enough to obtain discrimination enantiomers; these cases, sometimes this problem can be resolved using dual system. The systems often dramatically enhance enantioseparation selectivity applied for separation many...