The Western corn rootworm (WCR) and the European corn borer (ECB) are serious pests of maize in the U.S. Secondary infections with Fusarium verticillioides, F. proliferatum, and F. subglutinans occur after ECB larvae feeding, causing ear rots and contamination with fumonisin, a mycotoxin associated with severe animal and human health disorders. The tolerance of maize germplasm adapted to the Mi...

By employing serial enrichment, a derivative of Clostridium acetobutylicum ATCC 824 was obtained which grew at concentrations of butanol that prevented growth of the wild-type strain. The parent strain demonstrated a negative growth rate at 15 g of butanol/liter, whereas the SA-1 mutant was still able to grow at a rate which was 66% of the uninhibited control. SA-1 produced consistently higher ...

Evidence shows bidirectional crosstalk between neurons and glia, suggesting that glia play an active role in synaptic plasticity leading to chronic pain. Importantly, gliosis has been implicated in the development and maintenance of hyperalgesia or allodynia following chronic inflammation or nerve injury. Anandamide (AEA) and 2arachidonoylglycerol (2-AG), or the lipoamino acid N-arachydonoyldop...

The European Union (EU) countries have started the Economic and Monetary Union (EMU) on January 1, 1999. With the EMU, the EU countries replaced their national currencies and national monetary policy autonomy by a common currency, the Euro, and a common monetary policy that is designed and implemented by the European Central Bank (ECB). A common currency was considered to form the completion of...

We examine the role of money in the policies of the ECB, using introductory statements of the ECB President at the monthly press conferences during 1999-2004. Over time, the relative amount of words devoted to the monetary analysis has decreased. Our analysis of indicators of the monetary policy stance suggests that developments in the monetary sector, while somewhat more important in the later...

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In utero exposure to Delta(9)-tetrahydrocannabinol (Delta(9)-THC), the active component from marijuana, induces cognitive deficits enduring into adulthood. Although changes in synaptic structure and plasticity may underlie Delta(9)-THC-induced cognitive impairments, the neuronal basis of Delta(9)-THC-related developmental deficits remains unknown. Using a Boyden chamber assay, we show that agon...

objective(s) the mechanism(s) by which antidepressants regulate the hypothalamic-pituitary-adrenal (hpa) axis remain elusive. the endocannabinoid system (ecbs) which exhibits antidepressant potential, appears to regulate the hpa axis activity. therefore, we aimed to investigate the role of the ecbs in the action of doxepin including its effect on the hpa axis. materials and methods male wistar ...

Endocannabinoid (eCB) signaling mediates depolarization-induced suppression of excitation (DSE) and inhibition (DSI), two prominent forms of retrograde synaptic depression. N-Arachidonoylethanolamine (AEA) and 2-arachidonoylglycerol (2-AG), two known eCBs, are degraded by fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL), respectively. Selective blockade of FAAH and MAGL is c...

BACKGROUND R-flurbiprofen, one of the enantiomers of flurbiprofen racemate, is inactive with respect to cyclooxygenase inhibition, but shows analgesic properties without relevant toxicity. Its mode of action is still unclear. METHODOLOGY/PRINCIPAL FINDINGS We show that R-flurbiprofen reduces glutamate release in the dorsal horn of the spinal cord evoked by sciatic nerve injury and thereby all...