Scientific relevance . Endocrine disruptors affect the functioning of endocrine organs, which leads to adverse drug reactions. toxicity requires special attention in preclinical studies candidate medicinal products. Aim. The study aimed review international guidelines and approaches assessing risk associated with Discussion. This covers documents that provide a methodological framework for iden...

In this article we describe a series of strategic models of populations and individuals subject to challenge by endocrine disruptors. These models are not designed to be fitted to detailed data on specific species but rather are intended to provide general insights on the relative importance of different demographic mechanisms in the population context. Therefore, the models contain the minimum...

In the last 30 years, there is increasing concern about chemical pollutants that have the ability to act as hormone mimics. Because of structural similarity with endogenous hormones, their ability to interact with hormone transport proteins, or their ability to disrupt hormone metabolism, these environmental chemicals have the potential mimic, or in some cases block, the effects of endogenous h...

Environmental endocrine disruptors (EEDS) are those endocrine modifying chemicals that are also environmental pollutants. A brief description of known and suspected effects of these chemicals is presented along with a table of chemicals that are of interest for further study by three organisations. The future challenge to environmental chemists will be to develop sensitive, selective, and accur...