OBJECTIVE Connections between chronic inflammation and tumor development and progression are now generally accepted. Recent evidence indicates that hepatitis B is associated with several types of cancer, but whether endometrial carcinoma (EC) is included has not been reported. METHODS We analyzed HBV serum marker status in 398 patients with endometrial cancer, comparing them to 788 control wo...

FXYD3 expression is upregulated in numerous cancer cell types. The present study compared the FXDY3 expression in normal endometrium, premalignant lesion and endometrial cancer tissue samples, and investigated the correlation between FXDY3 expression and clinicopathological features. FXYD3 expression was analyzed by streptavidin-peroxidase immunohistochemistry in 21 normal endometrial tissue sa...

Background: Although the peak incidence of endometrial carcinoma is in postmenopausal women, it affects young women who wish to preserve fertility. The aim of this study was to assess oncologic and reproductive outcomes of fertility-sparing treatment using hysteroscopic resection followed by progesterone for early-stage endometrial carcinoma in young women in the western region of China. Method...

Background: Endometrial carcinoma develops through preliminary stages of endometrial hyperplasia. A population epithelial stem cells was identified in the human endometrium, these may serve as a source putative carcinoma. The most important member cancer cell markers is OCT-4. Both tumor proliferation (Ki-67) and angiogenesis seem to be for development aggressive tumors. Aim Work: This study ai...

Objective: To observe trends of gynaecological malignancies at Combined Military Hospital Lahore.
 Study Design: Cross-sectional study.
 Place and Duration Study: Lahore Pakistan, from Jan 2015 to Dec 2019.
 Methodology: Data was retrieved patient admission discharge notes their records the pathology department. Variables like malignancies, mean age, common presenting complaint, ...

Infertile women with chronic anovulation are prone to be exposed to unopposed estrogen stimulation and have the high risk of being suffering from endometrial hyperplasia or even endometrial carcinoma. A few reports have suggested that nulliparous young women (under 40 yr of age) with endometrial carcinoma could be treated conservatively to preserve fertility and succeed the live birth. We repor...

The high-mobility group A protein 2 (HMGA2) is a non-histone chromatin factor highly expressed in fetal tissue and malignant tumors but rarely detected within normal adult tissues. The clinical implications and biological functions of HMGA2 in endometrial carcinoma are largely unknown. Here we report that HMGA2 expression was barely detected in benign endometrium samples (2 of 28 samples). Howe...

OBJECTIVE The aim of this study was to determine the expression of S100 positive dendritic cells (DCs) and the relationship with clinicopathologic factors in endometrial carcinoma. METHODS Samples were collected from 89 patients with endometrial endometrioid adenocarcinoma treated in Pusan National University Hospital from 2004 to 2011. Normal endometrial tissues were obtained from 30 hystere...

BACKGROUND Although alterations in the mechanisms of apoptosis are an integral part of the tumor phenotype, their precise role in endometrial carcinoma is still obscure. The aim was to determine whether Bcl-2 plays a similar biological role in endometrial cancer as in breast cancer, endometrial cancer being also a hormone-dependent tumor. MATERIALS AND METHODS The expression of the apoptosis-...

Phosphatase and tensin homolog (PTEN) is a protein that acts as a tumor suppressor by dephosphorylating the lipid second messenger phosphatidylinositol 3,4,5-trisphosphate. Loss of PTEN function has been implicated in the pathogenesis of a number of different tumors, particularly endometrial carcinoma (ECa). ECa is the most common neoplasia of the female genital tract. Our study evaluates an as...