On the basis of clinical and pathologic criteria, endometrial carcinoma has been distinguished as types I (mainly endometrioid) and II (nonendometrioid). Limited data suggest that these subtypes have different risk factor profiles. The authors prospectively evaluated risk factors for types I (n = 1,312) and II (n = 138) incident endometrial carcinoma among 114,409 women in the National Institut...

Endometrial cancer is the most common gynecological in developed countries, second poor countries and developing after cervical cancer. Most endometrial patients come with complaints of bleeding at an early stage. It’s important to make right diagnosis determine appropriate treatment. Treatment depends on stage determined by surgery. After surgery, patient’s risk was classified as low, moderate...

Objective: This retrospective descriptive study to, assess the expression of Her-2 in endometrial carcinoma & to correlate the results with other known clinic pathologic features in Sudanese patients . Material and Methods: Twenty three (23) paraffin-embedded formalin-fixed tissue blocks of endometrial carcinoma were stained by immunoperoxidase stains for Her-2/neu (DAKO, Denmark), collected wi...

OBJECTIVE Endometrial cancer is the fourth most common cancer among women in developed countries. Affected patients may benefit from systemic chemotherapy, alone or in combination with targeted therapies if the disease is clinically diagnosed prior to expansion and metastasis to other organs.The aim of this study was to evaluate the prognostic role of c-kit mutations and comparision with tumor ...

Objective: This study aims to investigate the expression of g-synuclein in endometrioid endometrial carcinoma and assess if the g-synuclein expression correlates with the aggression of the tumour and its prognostic value in endometrioid endometrial carcinoma. Design: This retrospective study evaluated (60) specimens of the primary untreated endometrioid endometrial carcinoma and (12) normal end...

OBJECTIVES STAT3 is over-expressed in endometrial cancer, and diabetes is a risk factor for the development of type 1 endometrial cancer. We therefore investigated whether glucose concentrations influence STAT3 expression in type 1 endometrial cancer, and whether such STAT3 expression might be inhibited by metformin. METHODS In Ishikawa (grade 1) endometrial cancer cells subjected to media wi...

Human endometrial glands synthesize and secrete a high molecular weight mucin-like glycoprotein in a menstrual cycle-dependent fashion. A novel moiety within this Golgi-associated glycoprotein is strongly reactive with IgG antibodies in numerous murine ascites, and has been termed MAG (mouse ascites Golgi). Immunohistochemical staining of 201 endometrial biopsies revealed the following patterns...

© 2009 The Authors. doi: 10.2340/00015555-0718 Journal Compilation © 2009 Acta Dermato-Venereologica. ISSN 0001-5555 Sir, Uterine papillary serous carcinoma (UPSC) was established as a distinct type of endometrial carcinoma by Lauchlan (1) in 1981 and Hendrickson et al. (2) in 1982. UPSC currently constitutes 4% of all endometrial carcinomas and histologically resembles papillary serous adenoca...

introduction: to evaluate the efficacy and safety of carboplatin plus paclitaxel in patients with advanced locoregional recurrence and metastatic endometrial cancer. patient and method: 32 eligible patients (median age 62, range 41-72) with measurable endometrial cancer were treated with carboplatin (auc= 6) and paclitaxel (175 mg/m 3 ) every 4 weeks for 6 cycles, or, until disease progression ...

Estrogen production and metabolism play critical roles in the development and pathogenesis of endometrial carcinoma. Cytochrome P450 1B1 (CYP1B1) and catechol-O-methyltransferase (COMT) are two key enzymes in the estrogen metabolism pathway that result in the hydroxylation and conjugation of estradiol, respectively. We evaluated the association between the CYP1B1 Leu432Val and CYP1B1 Asn453Ser ...