background: beta-adrenergic blocking agents have been broadly used for treatment of many cardiovascular diseases such as arterial hypertension and ischemic heart failure. anti-tumoral, anti-inflammatory and anti-angiogenesis effects of propranolol (a non-selective beta-adrenergic blocker) have been shown. angiogenesis (replenish of the pre-existing vascular networks) plays a critical role in so...

background: we investigated coronary angiogenesis and serum vascular endothelial growth factor (vegf) and its soluble receptor-1 (sflt-1) concentrations in two-kidney one-clip (2k1c) hypertensive rats before and after reversal of hypertension. methods: the animal groups were: (i) sham-clipped for 12 weeks; (ii) 2k1c for 12 weeks; (iii) sham-clipped for 12 weeks and unclipped for 12 weeks; and (...

we report a case of choroidal neovascularization (cnv) secondary to methylenetetrahydrofolate reductase (mthfr) gene mutation in a 20-year-old male patient with hypopituitarism. treatment with three consecutive injections of intravitreal ranibizumab (anti-vascular endothelial growth factor) resulted in significant improvement of the patient’s vision and the appearance of the macula. a search ...

Dengue virus (DENV) is a pathogenic arbovirus that causes human disease. The most severe stage of the disease (severe dengue) characterized by vascular leakage, hypovolemic shock, and organ failure. Endothelial dysfunction underlies these phenomena, but causal mechanisms endothelial are poorly characterized. This study investigated role c-ABL kinase in DENV-induced dysfunction. Silencing with a...

Amorphous calcium phosphate (aCaP) nanoparticles may trigger the osteogenic commitment of adipose-derived stem cells (ASCs) in vitro. The ASCs three human donors are investigated using basal culture medium DMEM to either 5 or 50 µg/mL aCaP suspension (control: no nanoparticles). After 7 14 days, cell marker genes, as well endothelial, osteogenic, chondrogenic, and adipogenic analyzed by qPCR. F...

the adhesion molecules are involved in adhesion of leukocytes to endothelial cells and other immune cells. not only adhesion molecules have membrane form, but they also have soluble form. in this paper, we attempted to investigate the concen¬tration of soluble adhesion molecules in the type 1 diabetic patients (n = 40) and healthy subjects (n = 10). the results indicated that there was an incre...

purpose: to evaluate the effect of vacuum and flow rate on endothelial cell loss after high versus low vacuum phacoemulsification. methods: this randomized clinical trial was performed on 60 eyes of 60 patients with moderate lens opacity (nuclear sclerosis 3+). all surgeries were performed by one experienced surgeon using stop and chop technique with sovereign white star machine (amo). patients...

Endothelial dysfunction which is manifested by the loss of nitric oxide bioavailability, is an increasingly recognized cause of cardiac syndrome X (CSX) and beta blockers are used for the treatment of this syndrome. Thus, the aim of this study was to investigate effects of metoprolol, as a beta blocker, on endothelial function in CSX patients. The study included 25 CSX patients (20 female/ 5 ma...