Chlorophyll (Chl) b is synthesized by oxidation of a methyl group on the B ring of the porphyrin molecule to a formyl group by chlorophyllide (Chlide) a oxygenase (CAO). The overexpression of Arabidopsis thaliana full length CAO (AtCAO) in tobacco (Nicotiana tabacum) resulted in an increased Chl synthesis and a decreased Chl a/b ratio in low-light-grown (LL) as well as in high-light-grown (HL) ...

Seventeen novel 3-methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxylate and -carboxamide derivatives were synthesized and evaluated for their growth inhibition in seven human solid tumor and a human leukemia HL-60 cell lines. Compound IVa showed more activity than the other compounds and the positive control temozolomide. In the presence of 40 μg/mL of IVa, the survival rate of...

Hodgkin lymphoma (HL) as a malignant tumor presents with lymphadenopathy and systemic complaints. The origin of this tumor is mostly suggested to be B lymphocytes. There is a close relationship between autoimmunity and HL, but the mechanism of this immune syndromes is unclear. Immune thrombocytopenia (ITP) is the most common autoimmune syndrome which may present before, at the same time, and ev...

Micromonas is a unicellular marine green alga that thrives from tropical to polar ecosystems. We investigated the growth and cellular characteristics of acclimated mid-exponential phase Micromonas commoda RCC299 over multiple light levels and over the diel cycle (14:10 hour light:dark). We also exposed the light:dark acclimated M. commoda to experimental shifts from moderate to high light (HL),...

A significant amount of data has been published over the past decade regarding the clinical utility of F-fluorodeoxyglucose positron emission tomography (FDG-PET) in the diagnosis and management of Hodgkin lymphoma (HL). This includes studies examining interim FDG-PET, which has been shown to be a strong tool for predicting relapse and survival, especially in advanced- stage HL. Despite progres...

Background: Given that Hodgkin’s lymphoma (HL) accounts for 5%–6% of pediatric malignancies, we investigated the clinical characteristics and survival of pediatric patients with HL in our center. Materials and methods: In this cross sectional and retrospective study, the medical charts of all patients under the age of 18 diagnosed with HL from 2006 to 2016 at Shahid Sadoughi Hospital Yazd, Ira...

Background: Hearing impairment is the most common otolaryngologic manifestation of aging. Objectives: Few studies have focused on Hearing Loss (HL) in the Iranian “normal” elderly population. This study aimed to evaluate audiological problems in the normal elderly people of the rural areas of Rasht City in the north of Iran. Materials & Methods: This cross-sectional study was conducted in 2...

As an initial step in the study of the influence of orthodontic force on cellular function in vitro, the effects of centrifugal force on the cytotoxicity induced by various apoptosis inducers were investigated. When human oral squamous cell carcinoma (HSC-2) and human promyelocytic leukemia (HL-60) cell lines were treated with increasing magnitudes of centrifugal force (evaluated by g-value), t...

In this paper we report that, like dimethyl sulfoxide (DMSO), retinoic acid (RA), and conditioned medium (CM) from lectin-stimulated mononuclear leukocytes, CM from a human null cell leukemia line (Reh) induces HL-60 promyelocytic leukemia cells to respond in an enhanced manner to phorbol diester (PDE). Furthermore, Reh-CM induces PDE-resistant HL-60-1E3 cells to respond to PDE and lyse target ...