Implicit in the application of the common-factor model as a method for decomposing trait covariance into a genetic and environmental part is the use of factor scores. In multivariate analyses, it is possible to estimate these factor scores for the communal part of the model. Estimation of scores on latent factors in terms of individual observations within the context of a twin/family study amou...

The environmental consequences of increasing human population size are dynamic and nonlinear, not passive and linear. The role of feedbacks, thresholds, and synergies in the interaction of population size and the environment are reviewed here, with examples drawn from climate change, acid deposition, land use, soil degradation, and other global and regional environmental issues. The widelyassum...

MOTIVATION Cells receive a wide variety of environmental signals, which are often processed combinatorially to generate specific genetic responses. Changes in transcript levels, as observed across different environmental conditions, can, to a large extent, be attributed to changes in the activity of transcription factors (TFs). However, in unraveling these transcription regulation networks, the...

This study explores the use of an individual's genetic (IGFS) and environmental factor score (IEFS), constructed using genetic model fitting of a multivariate strength phenotype. Maximal isometric and dynamic strength measures, one maximal repetition load (1RM) and muscle cross-sectional area (MCSA) were measured in 25 monozygotic and 16 dizygotic twin pairs. The use of IGFS and IEFS in predict...

OBJECTIVE Eating at "fast food" restaurants has increased and is linked to obesity. This study examined whether living or working near "fast food" restaurants is associated with body weight. METHODS A telephone survey of 1033 Minnesota residents assessed body height and weight, frequency of eating at restaurants, and work and home addresses. Proximity of home and work to restaurants was asses...

Studies attempting to identify environmental risk factors for diseases can be seen to extract candidate variables from remotely sensed datasets, using a single buffer-zone surrounding locations from where disease status are recorded. A retrospective case-control study using canine leptospirosis data was conducted to verify the effects of changing buffer-zones (spatial extents) on the risk facto...

AhR controls endotoxin tolerance pathway Transcription factor influences codon choice and protein evolution Human stem cells reveal gene-environment interaction in Parkinson’s disease New tool for assessing ovarian cancer Repairing UV-induced DNA damage One strain of bioremediation bacteria uses novel metabolic pathway Endoplasmic reticulum stress triggers obesity-driven liver cancer Phthalate ...

Entry into sporulation is governed by the master regulator Spo0A. Spo0A accumulates in its active form, Spo0A-P, as cells enter stationary phase. Prior reports have shown that the acute induction of constitutively active Spo0A during exponential growth does not result in sporulation. However, a subsequent study also found that a gradual increase in Spo0A-P, mediated through artificial expressio...

Ricardo J. Bosch, Borja Quiroga, Carmen Muñoz-Moreno, Nuria Olea-Herrero, María Isabel Arenas , Marta González-Santander, Paula Reventún , Carlos Zaragoza , Gabriel de Arriba y Marta Saura e a Laboratorio de Fisiología Renal y Nefrología Experimental, Unidad de Fisiología, Departamento de Biología de Sistemas, Universidad de Alcalá, Alcalá de Henares, España b Servicio de Nefrología, Hospital U...