S. Williams1, I.D. Davis2, C. Sweeney3, M.R. Stockler4, A. Martin4, A.P. Long4, S. Yip4, X. Coskinas4, P. Nguyen5 Radiation Oncology, Peter MacCallum Cancer Centre, Melbourne, VIC, AUSTRALIA Eastern Health Clinical School, Monash University, Melbourne, VIC, AUSTRALIA Lank Center for Genitourinary Oncology, Dana Farber Cancer Institute, Boston, MA, USA NHMRC Clinical Trials Centre, University of...

Immune response from STRIDE, a randomized, Phase II, open-label study of sipuleucel-T (sip-T) with concurrent vs sequential enzalutamide (enz) administration in metastatic castration-resistant prostate cancer (mCRPC) Charles G Drake, David Quinn, Robert Dreicer, Emmanuel Antonarakis, Neal Shore, John Corman, Raoul Concepcion, Christopher Pieczonka, Dwayne Campogan, Li-Qun Fan, Nancy Chang, Nade...

Persistent androgen receptor (AR) transcriptional activity underlies resistance to AR-targeted therapy and progression to lethal castration-resistant prostate cancer (CRPC). Recent success in retargeting persistent AR activity with next generation androgen/AR axis inhibitors such as enzalutamide (MDV3100) has validated AR as a master regulator during all stages of disease progression. However, ...

The appearance of a mutant androgen receptor, AR(F876L), in prostate cancer cells chronically exposed to enzalutamide or ARN-509 promotes a switch from antagonist to agonist receptor function, undermining the potential long-term effectiveness of these second-generation antiandrogen drugs.

The baseline value of neutrophil to lymphocyte ratio (NLR) has been found to be prognostic in patients with metastatic castration resistant prostate cancer (CRPC). We evaluated the impact of baseline NLR and its change in patients receiving enzalutamide. We included consecutive metastatic CRPC patients treated with enzalutamide after docetaxel and studies the change of NLR (>3 vs ≤3) after week...