chemotherapy research highly prioritizes overcoming the multidrug resistance (mdr) in human tumors. liposomal formulation of fluoxetine, as a fourth generation chemosensitizer, was constructed and characterized for percent entrapment, release profile, morphology, particle size, zeta potential and stability. liposomes were prepared using different active loading techniques. the influence of diff...

the ever severe dynamic competitive environment has led to increasing complexity of strategic decision making in giant organizations. strategy formulation is one of basic processes in achieving long range goals. since, in ordinary methods considering all factors and their significance in accomplishing individual goals are almost impossible. here, a new approach based on clustering method is pro...

in this study, the optimum combination of major factors affecting the acceptability of whey-based ricotta cheese i.e. fat at three levels (0, 5, 10%), salt at three levels (0, 1, 2%), and starter culture at two levels (0, 3%) was determined in a complete randomized design method with a factorial experiment. ricotta cheese trials made by mixing whey and milk in a ratio of 5:1 were then organ...

The sublingual mucosa is an appealing route for drug administration. However, in the context of increased use therapeutic proteins, development protein delivery systems that will protect bioactivity needed. As proteins are fragile and complex molecules, current formulations liquid dosage. Yet, dilution short residence time at main barriers control dose delivered. In this work, a simple scaffold...

Objective(s):Hyperglycemia mediated oxidative stress plays a key role in the pathogenesis of diabetic complications like nephropathy. In the present study, we evaluated the effect of ethanolic extract of Ensete superbum seeds (ESSE) on renal dysfunction and oxidative stress in streptozotocin-induced diabetic rats. Materials and Methods:Glucose, HbA1c, total protein, albumin, renal function mar...

The conversion of low-value byproducts to high value-added protein hydrolysates by enzymatic hydrolysis is among the top trends in food industry. Protein provide an opportunity for effective utilization and are considered promising functional ingredients. However, hydrolyzing effect contributes taste aroma defects such as fishy off-flavour bitterness that impeded their application. Several proc...

It has been argued that a substrate-induced conformational change involving the orientation of catalytic groups cannot affect the specificity for two substrates in an enzymatic system where the chemical step is rate limiting, because such an induced fit would alter the catalytic efficiency for both to an equal extent. To the contrary, the generalized induced-fit treatment described here shows t...

in this study, tretinoin microemulsion has been formulated based on phase diagram studies by changing the amounts and proportions of inactive ingredients, such as surfactants, co-surfactants and oils. the effects of these variables have been determined on microemulsion formation, particle size of the dispersed phase and release profile of tretinoin from microemulsion through dialysis membrane. ...

shampoos are products which remove surface grease and dirt from the hair shaft and scalp. the cleansing or detergent action of a shampoo is a primary function. however, the foaming characteristic of a shampoo has an important role in its acceptability. often alkanolamides are used for the formation of a stable foam; but because of producing nitrosamines, they are potentially carcinogenic compou...