although control charts are very common to monitoring process changes, they usually do not indicate the real time of the changes. identifying the real time of the process changes is known as change-point estimation problem. there are a number of change point models in the literature however most of the existing approaches are dedicated to normal processes. in this paper we propose a novel appro...

i.-Asparaginase is a chemotherapeutic agent that is also immunosuppressive, inhibiting both the cellular and hu moral responses. This study deals with the effects of the enzyme on lymphocyte surface receptors to the mitogen concanavalin A. We previously reported that short incu bation of lymphocytes with L-asparaginase leads to a de creased binding of the mitogen to their surface. We now re por...

Isomerization reactions are fundamental in biology, and isomers usually differ in their biological role and pharmacological effects. In this study, we have cataloged the isomerization reactions known to occur in biology using a combination of manual and computational approaches. This method provides a robust basis for comparison and clustering of the reactions into classes. Comparing our result...

Estrogen exposure is a risk factor for breast cancer. Given that HSD17B2 gene encodes an enzyme that catalyses estradiol inactivation, it appears as a good candidate breast cancer susceptibility gene. This study was designed to screen for HSD17B2 germline mutations potentially involved in breast cancer predisposition. Our re-sequencing analysis did not identify any deleterious germline mutation...

The Protein Data Bank contains the description of approximately 27 000 protein-ligand binding sites. Most of the ligands at these sites are biologically active small molecules, affecting the biological function of the protein. The classification of their binding sites may lead to relevant results in drug discovery and design. Clusters of similar binding sites were created here by a hybrid, sequ...

Enzyme profiles of eight Flavobacterium species and one Sphingobacterium species were compared after using a two-dimensional fluorescence technique. Enzyme contents and corresponding activities were rapidly determined for whole-cell preparations after incubation with a mixture of preselected fluorogenic substrates. A two-dimensional fluorescence spectrum of the resulting product mixture, measur...

laboratory diagnosis of acute measles is usually achieved by serology assays for measle-specific igm antibody. for comparison of measle-specific igm antibody in saliva and serum, 95 paired blood and saliva samples were collected 1-14 days after the onset of rash. the specimens were tested for specific igm antibody by an igm antibody-capture enzyme immunoassay (eia). measles igm antibody was det...

the aim of this study was to evaluate an enzyme - linked immunosorbent assay (elisa) for the detection of anti - helicobacter pylori (h. pylori) specific igg antibodies in specimens of oral fluid. all subjects over the age 18 years undergoing endoscopy for any reason were asked to participate in the study. two groups of 44 patients in each were selected as hp+ and hp-. at the same time, 5 milli...