Beams-eye-view imaging applications such as real-time soft-tissue motion estimation are hindered by the inherently low image contrast of electronic portal imaging devices (EPID) currently available for clinical use. We introduce and characterize a novel EPID design that provides substantially increased detective quantum efficiency (DQE), contrast-to-noise ratio (CNR) and sensitivity without deg...

AIM To compare the accuracy of radiotherapy set-up using an electronic portal imaging device (EPID) versus megavoltage cone beam computed tomography (MV-CBCT) in paediatric patients. MATERIALS AND METHODS In total, 204 pairs of EPID and MV-CBCT were carried out for 72 patients in the first 3 treatment days and weekly thereafter. RESULTS For the whole group, the mean systematic EPID set-up e...

PURPOSE A software program (MU-EPID) has been developed to perform patient specific IMRT pre-treatment QA verification using an electronic portal imaging device. METHODS The software converts measured images of intensity modulated beams delivered to an EPID, into fluence maps that can be imported in the treatment planning system. The dose can then be calculated in the patient anatomy and comp...

A practical and accurate generalized procedure to reconstruct the isocenter dose D(iso) for 3D conformal radiotherapy (3DCRT) has been developed for X-ray open beams supplied by linacs of different manufacturers and equipped with aSi electronic portal imaging devices (aSi EPIDs). This paper reports an extension of the method, to be applied at the wedged X-ray beams characterized by the wedge at...

ID: 5462 Title: Advances in Co-60 based Tomotherapy Including Megavoltage CT Purpose: To evaluate the potential for Co-60 based tomotherapy including dose delivery and mega-voltage CT (MVCT). Tomotherapy is a rotational implementation of IMRT that provides highly conformal doses and patient setup verification using MVCT. Current tomotherapy is limited to linear accelerators. This poster present...

PURPOSE To investigate the long term stability and viability of using EPID-based daily output QA via in-house and vendor driven protocol, to replace conventional QA tools and improve QA efficiency. METHODS Two Varian TrueBeam machines (TB1&TB2) equipped with electronic portal imaging devices (EPID) were employed in this study. Both machines were calibrated per TG-51 and used clinically since ...

1,25 dihydroxyvitamin D (1,25(OH)2D), the active metabolite of vitamin D, and calcium regulate epidermal differentiation. 1,25(OH)2D exerts its effects through the vitamin D receptor (VDR), a transcription factor in the nuclear hormone receptor family, whereas calcium acts through the calcium sensing receptor (Casr), a membrane bound member of the G protein coupled receptor family. We have deve...