نتایج جستجو برای: epidermal growth factor

تعداد نتایج: 1474872  

Journal: :Journal of Biological Chemistry 1997

2006
Kjersti A. Skantze Constance E. Brinckerhoff John P. Collier

Nonneoplastic cell lines are unable to grow in soft agar. However, concomitant treatment of these cells with epidermal growth factor and transforming growth factor ßconfers upon them anchorage independence. Since articular chondrocytes are unique as normal diploid cells that do have the capability of growing in soft agar, we tested whether transforming growth factor ßand epidermal growth fact...

2018
Sabrina Maisel Derrick Broka Joyce Schroeder

The Epidermal Growth Factor Receptor (EGFR) is frequently mutated and overexpressed in metastatic cancer. Although EGFR is a transmembrane tyrosine kinase localized to the basolateral membrane in normal epithelium, it is frequently found intracellularly localized in transformed cells. We have previously demonstrated the epithelial adaptor protein mucin 1 (MUC1) alters trafficking of EGFR, inhib...

Journal: :Cancer 1989
K Sugiyama Y Yonemura I Miyazaki

Immunohistochemical study for epidermal growth factor (EGF) and epidermal growth factor receptor (EGFR) was performed on 222 specimens of gastric carcinoma. The authors placed each carcinoma into one of the following three groups: group 1, neither EGF nor EGFR was stained (123 cases); group 2, either EGF or EGFR was stained (64 cases); and group 3, both EGF and EGFR were stained (35 cases). Com...

Journal: :Cancer research 2004
Maria L Amador Darin Oppenheimer Sofia Perea Anirban Maitra George Cusatis Christi Iacobuzio-Donahue Sharyn D Baker Raheela Ashfaq Chris Takimoto Arlene Forastiere Manuel Hidalgo

This study tested the hypothesis that the number of CA single sequence repeat (CA-SSR) in the intron 1 of the epidermal growth factor receptor (egfr) gene, which affects transcription efficiency of the gene, is associated with the response to EGFR inhibitors. To this end, we determined the number of CA dinucleotides in the intron 1 of the egfr gene in a panel of 12 head and neck cancer cell lin...

Journal: :Journal of High Institute of Public Health 2007

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