Treatment response in autoimmune epilepsy is variable. Achieving seizure reduction is often dependent on the specific neuronal antibody. Glutamic acid decarboxylase 65 (GAD65)-associated epilepsy is among the most challenging of the autoimmune epilepsies to treat, often requiring multiple antiepileptic drugs (AEDs) and aggressive immunotherapy to attain a reduction in seizure frequency. There h...

Patients with absence epilepsy fail to report almost 90% of their seizures. The clinical gold standard assess seizures is video-electroencephalography (vEEG) recorded in the hospital, an expensive and obtrusive procedure which requires also extended reviewing time. Wearable sensors, allow recording electroencephalography (EEG), accelerometer gyroscope have been used monitor epileptic patients h...

Clinical experience in open-label studies and anectodal reports suggest that levetiracetam is effective in generalized epilepsy. In this open-label prospective study, 19 patients (3 men, 16 women) affected by idiopathic generalized epilepsy were followed for at least 6 months following the introduction of levetiracetam. Patients were categorized according to syndrome subtype: juvenile myoclonic...

The International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE) have come to consensus definitions for the terms epileptic seizure and epilepsy. An epileptic seizure is a transient occurrence of signs and/or symptoms due to abnormal excessive or synchronous neuronal activity in the brain. Epilepsy is a disorder of the brain characterized by an enduring predispos...

Epilepsy is the most common brain diseases that cause many problems in the daily life of the patient. In most attempts to automatic detection, the attack used an EEG. In this paper, The complete data set consists of five sets recorded from normal and epileptic patients. Each set containing 100 single-channel EEG segments. Here we used first and last sets (A and E). Set A consisted of segments r...

Electroencephalography (EEG) is essential for the diagnosis of epilepsy, but it requires expertise and experience to identify abnormalities. It thus crucial develop automated models detection abnormalities in EEGs related epilepsy. This paper describes development a novel class compact convolutional neural networks (CNNs) detecting abnormal patterns electrodes The designed model inspired by CNN...

Seizure severity emerges as an important aspect of epilepsy. This is most relevant in refractory patients in whom complete remission of seizures is unlikely and reduced seizure severity may be a significant determinant of psychosocial well-being with a consequent improvement in quality of life (QOL). Thus a valid measure of seizure severity can serve both as an indicator of clinical outcome and...

PURPOSE Document the frequency, types and risk factors for injuries caused by seizures for people with childhood onset epilepsy. METHOD We contacted patients with all types of epilepsy except childhood absence from the Nova Scotia Childhood Epilepsy population-based cohort. Seizure onset was between 1977 and 1985. Patients and parents were asked about serious injuries resulting from a seizure...

PURPOSE Polymicrogyria (PMG) is an epileptogenic malformation of cortical development. We describe the clinical epilepsy and imaging features of a large cohort with PMG-related epilepsy. METHODS Participants were recruited through the Epilepsy Phenome/Genome Project, a multicenter collaborative effort to collect detailed phenotypic data on individuals with epilepsy. We reviewed phenotypic dat...