Epithelial dysplasia and carcinoma in-situ (CIS) of the oral mucosa are two different borderline grades similar to each other, and it is difficult for pathologists to distinguish these two lesions on hematoxylin and eosin-stained sections only. To support objective differential diagnoses, we have developed a new computer-aided analysis system. The method was based on a comparison of the elevati...

Background. The vast majority of malignant neoplasms the oral mucosa refer to squamous cell carcinomas. development carcinoma is often promoted by previous potentially diseases, with leukoplakia dominating among them. Objective. To determine clinical significance pathogenicity somatic mutations in mucosal leukoplakia. Methods. study material included 24 samples abnormal epithelium from patients...

Dysplasia grading is widely used to assess risk of transformation in oral potentially malignant disorders despite limited data on predictive value. DNA ploidy analysis has been proposed as an alternative. This study examines the prognostic value for both tests used in a routine diagnostic setting to inform clinical management. A retrospective study of conventional dysplasia grading was conducte...

OBJECTIVE To assess inter and intra observer variability in grading oral epithelial dysplasia (OED) using Smith and Pindborg grading system, WHO classification system and Brothwell DJ et al. classification system. STUDY DESIGN In the study 45 histological tissues of dysplasia, 15 each of mild, moderate and severe dysplasia were coded and blindly graded by three observers in three grading syst...

PURPOSE Identifying genes differentially expressed in nondysplastic BE (NDBE) from those expressed in high-grade dysplasia (HGD) should be of value in improving our understanding of this transition and may yield new diagnostic and/or prognostic markers. The aim of this study was to determine the differential transcriptome of HGD compared with NDBE through gene microarray analysis of epithelial ...

Among pancreatic cystic lesions, mucinous neoplasm (MCN) and intraductal papillary (IPMN) of the pancreas are precursor lesions adenocarcinoma. IPMN is characterized by proliferation mucin-producing epithelial cells that exhibit various degrees dysplasia. classified as main duct type (MD-IPMN), mixed branch (BD-IPMN) according to location involvement, into four histological subtypes (gastric, i...