the rate of cervical cancer in asians is deferent, based on the risk factors affecting and the rate of papiloma virus infection among females. cervical cancer is one of the important cancers between iranian women. in the present study the rate of cervical neoplasia was detected in isfahan and some risk factors affecting the incidence of cervical cancer was analyzed. the human papiloma virus inf...

BACKGROUND To investigate the indications of loop electrosurgical excision procedure (LEEP) and its overtreatment rates for the see and treat and three step strategies in cases of atypical squamous cells of undetermined cytology (ASC-US) and low grade intraepithelial neoplasia (LGSIL) cytology. MATERIALS AND METHODS We retrospectively analyzed colposcopy directed biopsy (CDB) and LEEP results...

HPVs (human papillomaviruses) infect epithelial cells and cause a variety of lesions ranging from common warts/verrucas to cervical neoplasia and cancer. Over 100 different HPV types have been identified so far, with a subset of these being classified as high risk. High-risk HPV DNA is found in almost all cervical cancers (>99.7%), with HPV16 being the most prevalent type in both low-grade dise...

Background and AimsThere is a lack of convenient, sensitive, noninvasive strategies for screening surveillance colorectal neoplasia. An assay combining the results circulating epithelial cells (CECs) somatic mutations cell-free DNA adjusting age/sex using unique algorithm evaluated in patients requiring colonoscopy.MethodsA prospective single-site 458-subject study (asymptomatic: 43% screening/...

Background:Squamous cell carcinoma (SCC) is the most common malignancy of the oral cavity, which is highly invasive. Verrucous carcinoma (VC) is the low-grade form of SCC. Epithelial dysplasia (ED) also has a malignant potential. This immunohistochemical (IHC) study aimed to assess angiogenesis and the presence of tumor-associated macrophages (TAMs) in SCC, VC and ED to determi...

objective: helicobacter pylori has a well-established role in the development of gastric cancer. in vitro studies reveal increased proliferation of the gastric mucosa in the presence of h. pylori infection. it has been also shown that production of some cytokines, such as interleukin-1 beta (il-1b) is increased in h. pylori infection. in addition, il-1b increases proliferation of gastric epithe...

OBJECTIVE Anal cytology is being increasingly used as part of anal cancer screening in patients at high risk for anal neoplasia. Most studies in anal cytology have focused on correlating the abnormal anal Pap smear with histopathologic outcomes. The aim of this study was to document histopathologic or repeat anal cytology outcomes in patients with unsatisfactory cytology. MATERIALS AND METHOD...