• Objective: To review the clinical trials of glycoprotein IIb/IIIa (GPIIb/IIIa) inhibitors for unstable angina or non–ST segment elevation myocardial infarction (MI) and to provide a practice guide for the use of these agents in this setting. • Methods: Clinical trials relating to GPIIb/IIIa antagonists and acute coronary syndromes were identified from a MEDLINE search of articles published be...

Protein disulfide isomerase (PDI) catalyzes the oxidation reduction and isomerization of disulfide bonds. We have previously identified an important role for extracellular PDI during thrombus formation in vivo. Here, we show that endothelial cells are a critical cellular source of secreted PDI, important for fibrin generation and platelet accumulation in vivo. Functional PDI is rapidly secreted...

conclusions the results of the present study indicate the protective effects of melissa officinalis on some sperm parameters and spermatogenesis quality in rats exposed to lead. background some medicinal plants with their antioxidant properties have protective effects on sperm parameters and neutralize the harmful effects of lead exposure. objectives the present study aimed to determine the eff...

Aim of the work: To evaluate the efficacy and safety of bolus only intra coronary platelet glycoprotein GP IIb/IIIa receptor antagonists combined with thrombus-aspiration during percutaneous coronary intervention (PCI) in ST-segment elevation myocardial infarction (STEMI). Patient and Methods: 25 consecutive STEMI patients treated by primary PCI including thrombus aspiration were prospectively ...