A 30-year-old healthy man came to our hospital with complaints of red, hot, and painful upper extremities which spontaneously appeared. These manifestations worsened with exercises and heat, but were alleviated by rest and cooling of the hands. There were 2 similar previous episodes of short duration. The patient was a healthy, non-alcoholic, non-smoker with no history of using medicine. ...

836 © 2007 The Authors JEADV 2007, 21, 822–849 Journal compilation © 2007 European Academy of Dermatology and Venereology 5 Hesse S, Berbis P, Privat Y. Keratoderma palmoplantaris papulosa (Bushcke–Fischer’s disease): efficacy of acitretin. Br J Dermatol 1993; 128: 104–105. 6 Horikoshi M, Kuroda K, Tajima S. Puncate palmoplantar keratoderma with pigmentary lesions on the dorsa of feet and ankle...

Chronic pain is one of the most common symptom seen in the clinical practice; it affects about 30% of adults in the world [1] leading to a poor quality of life and a higher risk to develop comorbidities such as depression. Available treatments often produce insufficient pain relief; thus the general therapeutic approach is still a stepwise process aimed to identify which drugs or drug combinati...

BACKGROUND Erythromelalgia (EM) is a chronic disorder characterized by intermittent pain, warmth and erythema of the extremities. Symptoms can be precipitated by increasing the temperature of the affected limb and can be partially relieved by direct cooling. MATERIALS AND METHODS Microvascular assessment was conducted under 'hot' (28 degrees C) environmental conditions in 61 EM (EMI) patients...

Essential thrombocythemia (ET) is a clonal stem cell disease characterized by isolated thrombocytosis and thrombohemorrhagic complications. We describe an unusual case of ET primarily presenting with skin symptoms including erythromelalgia and livedo reticularis (racemosa-type). Persistent thrombocytosis, bone marrow findings, JAK2 gene mutation, and markedly decreased ristocetin-cofactor activ...

Erythromelalgia is a rare, chronic, debilitating condition characterized by redness, warmth, and severe burning pain of the distal extremities. The feet are more commonly affected than the hands. Pain is precipitated by increases in temperature and by exercise. Patients often obtain relief by immersing the affected extremity in cold water. The pain is often refractory to treatment. For many pat...

The concept of chemiosmotic systems arises from the pioneering work of Peter Mitchell on two fronts. One is concerned with the mechanisms by which molecules are transported across membranes which are generally barriers to such transport. These mechanisms are inevitably molecular, and are now yielding their secrets to a combination of structural protein chemistry and molecular biology. The other...