نتایج جستجو برای: esophageal adenocarcinoma

تعداد نتایج: 104941  

2015
Claire Palles Laura Chegwidden Xinzhong Li John M. Findlay Garry Farnham Francesc Castro Giner Maikel P. Peppelenbosch Michal Kovac Claire L. Adams Hans Prenen Sarah Briggs Rebecca Harrison Scott Sanders David MacDonald Chris Haigh Art Tucker Sharon Love Manoj Nanji John deCaestecker David Ferry Barrie Rathbone Julie Hapeshi Hugh Barr Paul Moayyedi Peter Watson Barbara Zietek Neera Maroo Laura Gay Tim Underwood Lisa Boulter Hugh McMurtry David Monk Praful Patel Krish Ragunath David Al Dulaimi Iain Murray Konrad Koss Andrew Veitch Nigel Trudgill Chuka Nwokolo Bjorn Rembacken Paul Atherfold Elaine Green Yeng Ang Ernst J. Kuipers Wu Chow Stuart Paterson Sudarshan Kadri Ian Beales Charles Grimley Paul Mullins Conrad Beckett Mark Farrant Andrew Dixon Sean Kelly Matthew Johnson Shahjehan Wajed Anjan Dhar Elinor Sawyer Rebecca Roylance Lynn Onstad Marilie D. Gammon Douglas A. Corley Nicholas J. Shaheen Nigel C. Bird Laura J. Hardie Brian J. Reid Weimin Ye Geoffrey Liu Yvonne Romero Leslie Bernstein Anna H. Wu Alan G. Casson Rebecca Fitzgerald David C. Whiteman Harvey A. Risch David M. Levine Tom L. Vaughan Auke P. Verhaar Jan van den Brande Eelke L. Toxopeus Manon C. Spaander Bas P.L. Wijnhoven Luc J.W. van der Laan Kausilia Krishnadath Cisca Wijmenga Gosia Trynka Ross McManus John V. Reynolds Jacintha O’Sullivan Padraic MacMathuna Sarah A. McGarrigle Dermot Kelleher Severine Vermeire Isabelle Cleynen Raf Bisschops Ian Tomlinson Janusz Jankowski

BACKGROUND & AIMS Barrett's esophagus (BE) increases the risk of esophageal adenocarcinoma (EAC). We found the risk to be BE has been associated with single nucleotide polymorphisms (SNPs) on chromosome 6p21 (within the HLA region) and on 16q23, where the closest protein-coding gene is FOXF1. Subsequently, the Barrett's and Esophageal Adenocarcinoma Consortium (BEACON) identified risk loci for ...

Journal: :JAMA 2014
Megan A Adams Parul Divya Parikh Kwon Miller Joel H Rubenstein

Medical Professional Liability Claims Related to Esophageal Cancer Screening Endoscopic screening for esophageal adenocarcinoma has been recommended for patients with chronic symptoms of gastroesophageal reflux disease, but only if they have additional risk factors.1-3 Surveys of gastroenterologists indicate that concern about litigation for missing a cancer may drive endoscopy use in patients ...

2016
Amer Chaikhouni

Gastric and colon interposition are the commonly used in esophageal operations. In this report, Two jejunal esophageal interposition cases are presented. In the first patient, a free jejunal interposition graft was used to re-establish swallowing route in a patient who suffered severe esophageal and gastric chemical burn, and failure of colon interposition graft. The second patient had a leak o...

2016
Cheng Tan Xia Qian Zhifeng Guan Baixia Yang Yangyang Ge Feng Wang Jing Cai

Esophageal cancer, which consist of esophageal adenocarcinoma and esophageal squamous cell carcinoma, is one of the most common malignant tumors in the world, especially in the south of Iran and China. To find and investigate the biomarkers in the initiation, development and progression of esophageal cancer will help us predict the prognosis of esophageal cancer patients and improve the curativ...

Journal: :Cancer research 1996
Z T Hammoud Z Kaleem J D Cooper R S Sundaresan G A Patterson P J Goodfellow

The incidence of esophageal adenocarcinoma has increased dramatically over the past 20 years. The causes for this change in incidence and the genetic defects that underlie tumorigenesis are unknown. We performed loss of heterozygosity (LOH) studies in esophageal adenocarcinomas in an effort to map the location of tumor suppressor genes involved in the initiation or progression of this cancer. A...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2009
Ewy A Mathé Giang Huong Nguyen Elise D Bowman Yiqiang Zhao Anuradha Budhu Aaron J Schetter Rosemary Braun Mark Reimers Kensuke Kumamoto Duncan Hughes Nasser K Altorki Alan G Casson Chang-Gong Liu Xin Wei Wang Nozomu Yanaihara Nobutoshi Hagiwara Andrew J Dannenberg Masao Miyashita Carlo M Croce Curtis C Harris

PURPOSE The dismal outcome of esophageal cancer patients highlights the need for novel prognostic biomarkers, such as microRNAs (miRNA). Although recent studies have established the role of miRNAs in esophageal carcinoma, a comprehensive multicenter study investigating different histologic types, including squamous cell carcinoma (SCC) and adenocarcinoma with or without Barrett's, is still lack...

Journal: :Annals of surgery 2004
Mohamed M M Abdel-Latif James O'Riordan Henry J Windle Eleanor Carton Nagunivan Ravi Dermot Kelleher John V Reynolds

OBJECTIVE To examine the expression of the transcription factor nuclear factor kappa B (NF-kappaB) in Barrett's epithelium and adenocarcinoma and the impact of NF-kappaB expression on tumor stage and response to neoadjuvant chemotherapy and radiation therapy. SUMMARY BACKGROUND DATA Progression of Barrett's esophagus to adenocarcinoma is associated with a wide range of cellular and molecular ...

Journal: :Cancer research 2000
R F Souza K Shewmake D G Beer B Cryer S J Spechler

Adenocarcinoma in Barrett's esophagus has been increasing in incidence at a rapid rate for more than two decades. Cyclooxygenase (COX)-2 appears to play an important role in gastrointestinal carcinogenesis, and COX-2 overexpression has been demonstrated both in esophageal adenocarcinomas and in the metaplastic epithelium of Barrett's esophagus. The aim of our study was to determine whether sele...

Journal: :The American journal of clinical nutrition 2013
András P Keszei R Alexandra Goldbohm Leo J Schouten Paula Jakszyn Piet A van den Brandt

BACKGROUND Dietary N-nitroso compounds and endogenous nitrosation are important carcinogenic factors, but human evidence of their role is scarce for esophageal cancer and inconsistent for gastric cancer. OBJECTIVE We studied the relation between risks of esophageal and gastric cancer subtypes and dietary intake of N-nitrosodimethylamine, heme iron, nitrite, and nitrate in the Netherlands Coho...

Journal: :Oncology reports 2008
Ines Gockel Markus Moehler Kirsten Frerichs Daniel Drescher Tran Tong Trinh Friedrich Duenschede Thomas Borschitz Katrin Schimanski Stefan Biesterfeld Kerstin Herzer Peter R Galle Hauke Lang Theodor Junginger Carl C Schimanski

This study aimed to define the co-expression pattern of target receptor tyrosine kinases (RTKs) in human esophageal adenocarcinoma and squamous cell cancer. The co-expression pattern of vascular endothelial growth factor receptor (VEGFR)1-3, platelet-derived growth factor receptor (PDGFR)alpha/beta and epidermal growth factor receptor 1 (EGFR1) was analyzed by RT-PCR in 50 human esophageal canc...

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