Reflux of gastric contents can lead to development of reflux esophagitis and Barrett’s esophagus. Barrett’s esophagus is a risk factor for esophageal adenocarcinoma. Damage to DNA may lead to carcinogenesis but is repaired through activation of pathways involving polymorphic enzymes, including human 8-oxoguanine glycosylase 1 (hOGG1), X-ray repair cross-complementing 1 (XRCC1), and xeroderma pi...

BACKGROUND Gastroesophageal reflux disease (GERD) affects 15-25% of children and adolescents in the United States. The diagnosis of GERD in children is complex as reported symptoms or symptom profiles have been found to be unreliable. Frequently, the diagnosis must be confirmed by objective tests such as pH monitoring or histological evidence of esophagitis on an esophageal biopsy. Dental erosi...

Introduction: Inhaled & systemic steroids are one of the well-documented risks factors for Candida esophagitis. However, the role of gastric acid suppression remains controversial. Methods: We conducted a retrospective case-control study of 420 patients consisting of 84 cases of Candida esophagitis and 336 matched controls. Our cohort was gathered from subjects evaluated from 2001 to 2012. The ...

Background. Eosinophilic esophagitis (Ee) is a chronic immune-mediated disease of the esophagus, which characterized by symptoms esophageal dysfunction and marked eosinophilic infiltration mucous membrane (MM) organ. Currently, interest in problem global medical scientific community steadily growing. has no pathognomonic symptoms, causes great difficulty for diagnosis. Clinical case description...

background and aim: the purpose of present study was to evaluate endoscopic features, prevalence of complications, response to treatment and necessity of the endoscopy in the patients with gastroesophageal reflux disease (gerd) symptoms. materials and methods: we selected the patients with gerd symptoms in amiralmomenin hospital from 1381 to 1382. 277 cases were tested in this study. group 1, (...

OBJECTIVE To determine the prevalence of synchronous airway lesions and esophagitis in children younger than 18 months undergoing adenoidectomy for adenoid hypertrophy and upper airway obstruction. DESIGN Retrospective review spanning 4.5 years. SETTING Tertiary care children's hospital. PATIENTS All children younger than 18 months who underwent adenoidectomy for upper airway obstruction ...

In recent years, several randomized controlled trials and meta-analyses have evaluated the efficacy of the various therapeutic options available for treating patients with eosinophilic esophagitis, including dietary modifications, proton pump inhibitors, topical corticosteroids, and endoscopic esophageal dilation. Proton pump inhibitors are currently considered the first-line treatment for eosi...