INTRODUCTION In a preceding trial comparing two different titration schemes, insulin degludec/insulin aspart (IDegAsp) showed good efficacy for achieving HbA1c <7% when administered twice daily (BID) in patients with uncontrolled type 2 diabetes (T2D). However, poor glycemic control persisted in a minority of patients. The current exploratory trial investigated the efficacy and safety of intens...

The amount of wrack deposited and retained on a beach may be affected by the beach’s morphology. Conversely, wrack deposits have the potential to modify sediment dynamics on the beach face through accumulation and erosion of sediments around wrack deposits, and the incorporation of organic matter into beach sands. The aims of this chapter were thus to determine whether beach morphology differed...

the prime graph $gamma(g)$ of a group $g$ is a graph with vertex set $pi(g)$, the set of primes dividing the order of $g$, and two distinct vertices $p$ and $q$ are adjacent by an edge written $psim q$ if there is an element in $g$ of order $pq$. let $pi(g)={p_{1},p_{2},...,p_{k}}$. for $pinpi(g)$, set $deg(p):=|{q inpi(g)| psim q}|$, which is called the degree of $p$. we also set $d(g):...

We assessed the blockade of the renin-angiotensin system (RAS) achieved with 2 angiotensin (Ang) antagonists given either alone at different doses or with an ACE inhibitor. First, 20 normotensive subjects were randomly assigned to 100 mg OD losartan (LOS) or 80 mg OD telmisartan (TEL) for 1 week; during another week, the same doses of LOS and TEL were combined with 20 mg OD lisinopril. Then, 10...

This paper proposes a holistic equilibrium theory of organizational development (OD). The theory states that there are three driving forces in organizational change and development—rationality, reality, and liberty. OD can be viewed as a planned process of change in an organization so as to establish equilibrium among these three interacting forces. Existing OD theories, concepts and their impl...

Grande Riviere Beach in Trinidad and Tobago is an important nesting site in the Caribbean for the Critically Endangered leatherback sea turtle, Dermochelys coriacea. Community members were concerned that beach erosion and seasonal river flooding were destroying many of the nests deposited annually and thought that a hatchery was a possible solution. Over the 2001 turtle nesting season, the Inst...

The diameter diam(H) of a (directed) graph H is the maximum value computed over the lengths of all shortest (directed) paths in H . Given a bridgeless connected graph G, the oriented diameter OD(G) is given by OD(G) = min{diam(H) : H is an orientation of G}. In this paper, we show that OD(G) ≤ 2diam(G) +1 for every connected bridgeless interval graph G. Further, for every 2-connected proper int...

The establishment of the European Common Market has involved the free movement not only of capital and goods, but also of persons and services. The principles of free movement also apply to the health care sector, i.e. they allow for the free incorporation of health care providers and the cross-border delivery of services. Since the 1970s, the European Union (EU) has passed numerous regulations...

Driven by the increasing demand, grid technology is entering the business market in form of utility computing, grid middleware and grid-enabled application. However, the business market is interested in complete grid solutions. This means that for a successful take up of grid technology on the business market the establishment of grid value networks is required. This again can only be achieved ...

In this paper we investigate the effect of internationalization on home market performance using survey data and financial statement data of German insurance groups with property-liability business for the years 1999 through 2009. We develop a resource-based perspective and argue that strategic transformation is a major factor driving insurance groups’ internationalization, whereby successful i...