Materials. Ethylbromoacetate (97%), potassium carbonate (99%), diethyl ether (99.8%), ethylenediamine (99%), dichloromethane (99.6%), sodium triacetoxyborohydride (97%), sodium borohydride (98%), propionaldehyde (97%), poly(ethylene glycol) methyl ether thiol (PEG-SH, average mw 2000), formic acid (96%), formaldehyde (37% wt in H2O), sodium hydroxide(97%), propionaldehyde (97%), trifluoroacetic...

Earlier studies have shown that transferrin-gallium inhibits cellular iron incorporation and blocks DNA synthesis by decreasing the activity of the iron-dependent M2 subunit of ribonucleotide reducÃ-ase.We ex amined the growth-inhibitory effects of gallium nitrate in combination with clinically relevant inhibitors of ribonucleotide reducÃ-asefludarabine (an Ml subunit inhibitor), and iron chela...

The complex [Gd(L)(H2O)]3- (H(6)L =N,N'-bis(6-carboxy-2-pyridylmethyl)ethylenediamine-N,N'-methylenephosphonic acid) displays the highest water exchange rate ever measured for a Gd(III) chelate (k(298)(ex)= 8.8 x 10(8) s(-1)), which is attributed to the flexibility of the metal coordination environment.

The reactions of N1,N2-Di-boc-1,2,4-triaminobutane with bridged dicarboxylic acids afford the corresponding bis-amides from which – after removal of the Boc groups – bis(N,N′-bidendate) ligands H2NCH2CH(NH2)(CH2)2NHCO-X-CONH(CH2)2CH(NH2)CH2NH2 can be obtained. New examples are the reactions of the triaminobutane with pyridine-2,6-dicarboxylic acid, with phenylene-1,4-diacetic acid, with terepht...

1 The abbreviations used are: KDO, 3-Deoxy-D-manno-octulosonate; KDO 8-P, 3-DeoxyD-manno-octulosonate 8-phosphate; Tris, Tris-(hydroxymethyl)aminomethane; HEPES, N-[2Hydroxyethyl]piperazine-N’-[2-ethanesulfonic acid]; PNPase, purine nucleoside phosphorylase; EDTA, (ethylenedinitrilo)tetraacetic acid; 2D gel electrophoresis, two dimensional gel electrophoresis; SDS-PAGE, sodium dodecyl sulfate-p...

The rates of oxidation of four chelating agents with Ce(IV) in HC104 solutions, have been studied by the stopped-flow technique. The rates first increase with increasing acidity, reach maxima which are characteristic of the chelating agent and the medium, then progressively decrease with further increasing acid concentration. At their maximum reactivities, the tendencies for oxidation decrease ...