نتایج جستجو برای: evolving enhancer protein

تعداد نتایج: 1295154  

Journal: :iranian journal of pharmaceutical research 0
maryam tabarzad pharmaceutical biotechnology department, school of pharmacy, shahid beheshti university of medical sciences, tehran, iran. student's research committee, shahid beheshti university of medical sciences, tehran, iran. bahram kazemi cellular and molecular biology research center, shahid beheshti university of medical sciences, tehran, iran. biotechnology department, school of medicine, shahid beheshti university of medical sciences, tehran, iran. hossein vahidi department of pharmaceutical biotechnology, school of pharmacy, shahid beheshti university of medical sciences, tehran, iran. reza aboofazeli department of pharmaceutics, school of pharmacy, shahid beheshti university of medical sciences, tehran, iran. nastaran nafissi-varcheh pharmaceutical biotechnology derpartment, school of pharmacy, shahid beheshti university of medical sciences, tehran, iran.

aptamers, or single stranded oligonucleotides, are produced by systematic evolution of ligands by exponential enrichment, abbreviated as selex. in the amplification and regeneration step of selex technique, dsdna is conversed to ssdna. asymmetric pcr is one of the methods used for the generation of ssdna. the purpose of this study was to design a random dna library for selection of aptamers wit...

Journal: :Molecular and cellular biology 2006
Ken Shirakawa Shingo Maeda Tomomi Gotoh Makoto Hayashi Kenichi Shinomiya Shogo Ehata Riko Nishimura Masataka Mori Kikuo Onozaki Hidetoshi Hayashi Satoshi Uematsu Shizuo Akira Etsuro Ogata Kohei Miyazono Takeshi Imamura

Differentiation of committed osteoblasts is controlled by complex activities involving signal transduction and gene expression, and Runx2 and Osterix function as master regulators for this process. Recently, CCAAT/enhancer-binding proteins (C/EBPs) have been reported to regulate osteogenesis in addition to adipogenesis. However, the roles of C/EBP transcription factors in the control of osteobl...

Behrose S. Gandhi Poonam Singh, Priya Verma,

Objective(s):Bacopa monnieri (BM),a traditional ayurvedic medicine,is a well-known memory enhancer. We have explored the role of BM against decabrominated diphenyl ether (PBDE-209)-induced alterations in neonate and young female mice. Materials and Methods: Mice were orally administered with B. monnieri at the doses of 40, 80 or 120 mg/kg body weight along with PBDE-209 (20 mg/kg body weight) f...

Journal: :The Journal of pharmacology and experimental therapeutics 2004
Courtney E W Sulentic Wei Zhang Yong Joo Na Norbert E Kaminski

Transcriptional regulation of the Ig heavy chain gene involves several regulatory elements, including the 3'alpha enhancer, which is composed of four distinct regulatory domains. DNA binding sites for several transcription factors, including B cell-specific activator protein, nuclear factor for immunoglobulin kappa chain in B cells, and octamer have been identified within the 3'alpha enhancer d...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2002
Sebastián Kadener Juan Pablo Fededa Michael Rosbash Alberto R Kornblihtt

Promoters and enhancers are cis-acting elements that control gene transcription via complex networks of protein-DNA and protein-protein interactions. Whereas promoters deal with putting in place the RNA polymerase, both enhancers and promoters can control transcriptional initiation and elongation. We have previously shown that promoter structure modulates alternative splicing, strengthening the...

Journal: :The EMBO journal 1999
M J West J Karn

The human immunodeficiency virus type-1 (HIV-1) long terminal repeat (LTR) initiates transcription efficiently but produces only short transcripts in the absence of the trans-activator protein, Tat. To determine whether a cellular enhancer could provide the signals required to recruit an elongation-competent polymerase to the HIV-1 LTR, the B cell-specific immunoglobulin heavy chain gene enhanc...

Journal: :Cancer discovery 2017
Xiaosai Yao Jing Tan Kevin Junliang Lim Joanna Koh Wen Fong Ooi Zhimei Li Dachuan Huang Manjie Xing Yang Sun Chan James Zhengzhong Qu Su Ting Tay Giovani Wijaya Yue Ning Lam Jing Han Hong Ai Ping Lee-Lim Peiyong Guan Michelle Shu Wen Ng Cassandra Zhengxuan He Joyce Suling Lin Tannistha Nandi Aditi Qamra Chang Xu Swe Swe Myint James O J Davies Jian Yuan Goh Gary Loh Bryan C Tan Steven G Rozen Qiang Yu Iain Bee Huat Tan Christopher Wai Sam Cheng Shang Li Kenneth Tou En Chang Puay Hoon Tan David Lawrence Silver Alexander Lezhava Gertrud Steger Jim R Hughes Bin Tean Teh Patrick Tan

Protein-coding mutations in clear cell renal cell carcinoma (ccRCC) have been extensively characterized, frequently involving inactivation of the von Hippel-Lindau (VHL) tumor suppressor. Roles for noncoding cis-regulatory aberrations in ccRCC tumorigenesis, however, remain unclear. Analyzing 10 primary tumor/normal pairs and 9 cell lines across 79 chromatin profiles, we observed pervasive enha...

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