نتایج جستجو برای: excessive erythrocytosis
تعداد نتایج: 54835 فیلتر نتایج به سال:
Patients with a germline mutation in von Hippel-Lindau (VHL) develop renal cell cancers and hypervascular tumors of the brain, adrenal glands, and pancreas as well as erythrocytosis. These phenotypes are driven by aberrant expression of HIF2α, which induces expression of genes involved in cell proliferation, angiogenesis, and red blood cell production. Currently, there are no effective treatmen...
We describe here a family with autosomal dominant erythrocytosis. In in vitro cultures, performed using the methyl cellulose assay, the number of erythroid colonies was normal or marginally increased when a standard concentration of erythropoietin (Epo) was used, but at lower Epo concentrations, the investigated persons formed more colonies than the controls. The difference was generally greate...
Background. Paraneoplastic syndromes (PNS) such as hypercalcaemia, hypercholesterolaemia, and erythrocytosis have been described in hepatocellular carcinoma (HCC). Aims. (1) To examine the prevalence, clinical characteristics, and survival of PNS in HCC patients and (2) to evaluate the extent to which each individual PNS impacts on patient survival. Methods. We prospectively evaluated the preva...
RYTHROPOIETIN (Ep) is a glycoprotein hormone E produced mainly by the kidney and is the principle regulator of erythropoiesis.' The level of Ep is normally tightly controlled and helps to maintain a relatively constant red blood cell (RBC) mass.' Occasionally, abnormal production of Ep results in secondary erythrocytosis. Secondary erythrocytosis has been reported in a variety of tumors includi...
OBJECTIVE Myeloproliferative neoplasms (MPNs) like essential thrombocythemia (ET), polycythemia vera (PV), and primary myelofibrosis (PMF) are acquired clonal hematopoietic stem cell disorders and originate from a multipotent hematopoietic stem cell. The SOCS1 and SOCS3 genes are negative regulators of the JAK/STAT signal pathway. In this study we investigate the promoter methylation of these g...
Erythrocytosis was induced in Fischer rats by intrarenal (ir) injection of nickel subsulfide (Ni3S2) in dosages ranging from 0.6 to 10 mg per rat. Measurements of blood packed cell volume (PCV) became increased by one month after ir injection of Ni3S2; reached maximum values at approximately two months; and gradually returned to control values by seven months. The duration and magnitude of eryt...
13. Wiekre CG. Norman DJ. Bennison A. Barry JM. Bennett WM. Postrenal transplant erythrocytOSis: a review of 53 patients. Kidney Int 1983: 23: 73l. 14. Friman S. Nyberg G. Blohme l. Erythrocytosis after renal transplant: treatment by removal of the native kidneys. Nephrol Dial Transplant 1990: 5: 969. 15. Bakris GL. Sauter ER. Hus8ey JL. Fisher JW. Gaber AO. Winsett R. Effects of theophylline o...
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