High spinal cord injuries (SCI) lead to permanent respiratory insufficiency, and the search for new therapeutics restore this function is essential. To date, most documented preclinical model high SCI rat cervical C2 hemisection. However, molecular studies with are limited due poor availability of genetically modified specimens. The aim work was evaluate pathophysiology activity following a inj...

Abstract Epilepsy is a common neurological disease caused by synchronous firing of hyperexcitable neurons. Currently, anti-epileptic drugs remain the main choice to control seizure, but 30% patients are resistant drugs, which calls for more research on new promising targets. Neuroinflammation closely associated with development epilepsy. As an important inflammatory factor, high mobility group ...

OBJECTIVE Aberrations in brain development may lead to dysplastic structures such as periventricular nodules. Although these abnormal collections of neurons are often associated with difficult-to-control seizure activity, there is little consensus regarding the epileptogenicity of the nodules themselves. Because one common treatment option is surgical resection of suspected epileptic nodules, i...

Individuals differ in the intrinsic excitability of their corticospinal pathways and, perhaps more generally, their entire nervous system. At present, we have little understanding of the mechanisms underlying these differences and how variation in intrinsic excitability relates to behavior. Here, we examined the relationship between individual differences in intrinsic corticospinal excitability...