OBJECTIVES We evaluated the clinical significance of reciprocal ST-segment depression associated with exercise-induced ST-segment elevation for detecting residual viability within the infarcted area. BACKGROUND Although the relation between residual viability and exercise-induced ST-segment elevation has been described, there are no reports focusing on the relation between myocardial viabilit...

BACKGROUND The two main mechanisms of resistance to EGFR tyrosine kinase inhibitors (TKIs) in non-small cell lung cancer (NSCLC) are the occurrence of T790M secondary mutation in the kinase domain of EGFR and MET amplification. The aim of the present study was to test whether early changes of 18F-fluorodeoxyglucose (18F-FDG) uptake in animal models bearing erlotinib-resistant NSCLC may have dif...

OBJECTIVE Variable uptake of 2-deoxy-2-[18F]fluoro-D-glucose (FDG) has been noticed in positron emission tomography (PET) studies of gastric carcinoma patients, with low uptake occurring especially in some particular histological subtypes and early carcinomas. But this phenomenon has not been adequately explained. The aim of the present study is to clarify FDG uptake in gastric carcinomas espec...

Background: Malignant pleural mesothelioma is an aggressive neoplasm with a highly variable course. This pilot study evaluated the significance of the pattern, intensity and kinetics of F-FDG uptake in mesothelioma in the context of histopathology and surgical staging. Methods: Sixteen consecutive patients with pleural disease on CT scan underwent F-FDG imaging. Imaging was performed with a dua...

UNLABELLED We have previously demonstrated in vitro and in vivo that tumor uptake of FDG is markedly diminished by acute hyperglycemia. This in vitro study was designed to determine if tumor uptake of PET tracers (FDG, thymidine, L-methionine and L-leucine) is affected by acute or chronic hyperglycemia. METHODS Human ovarian adenocarcinoma (HTB 77 IP3) cells were grown in media containing 100...

Objective(s): We aimed to assess the association between blood pressure and LV myocardial uptake of FDG, hypothesizing that subjects with raised blood pressure would have higher FDG uptake. Methods: We analyzed 86 healthy controls who underwent PET/CT imaging 180 minutes following FDG (4 MBq/Kg) administration. LV myocardial analysis was perf...

the use of [18f]-2-fdg has been increasing in recent years. this agent was originally used for evaluation of cns glucose uptake and pathologic conditions by positron emission tomography (pet). in view of increasing demand for this agent, its production has been started at cyclotron dept., nuclear research center for agriculture & medicine-karaj iran (nrcam). in this paper, [18f]-fdg synthes...

Adrenal lesions are commonly observed during 18F-FDG PET/CT studies. Although, most of these lesions are considered benign, an important consideration in oncologic patients is metastasis. Benign lesions, such as adenomas usually present with low 18F-FDG uptake, although overlap with malignant lesions exist and clear SUV cut-off for distinguishing adrenal adenomas has not b...

PURPOSE In patients with soft-tissue sarcoma (STS), the early assessment of treatment responses is important. Using positron emission tomography/computed tomography (PET/CT) with [(18)F]fluorodeoxyglucose (FDG), we determined whether changes in tumor FDG uptake predict histopathologic treatment responses in high-grade STS after the initial cycle of neoadjuvant chemotherapy. EXPERIMENTAL DESIG...

Fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) is widely applied in non‐small cell lung cancer (NSCLC). The standardized uptake value (SUV), a semi‐quantitative index, plays an essential role in NSCLC for diagnosis, staging, and efficacy evaluation. It has been proposed that the SUVmax of tumors may correlate with the presence or absence of chemotherapy resista...