نتایج جستجو برای: exhausted cd4 t cell
تعداد نتایج: 2183294 فیلتر نتایج به سال:
The immune response plays an important role in staving off cancer; however, mechanisms of immunosuppression hinder productive anti-tumor immunity. T cell dysfunction or exhaustion in tumor-bearing hosts is one such mechanism. PD-1 has been identified as a marker of exhausted T cells in chronic disease states, and blockade of PD-1-PD-1L interactions has been shown to partially restore T cell fun...
It remains uncertain whether full T cell reconstitution can be established in HIV-infected children and adults with long-term sustained virological control by highly active antiretroviral therapy (HAART). In this study, we comprehensively analyzed various phenotypical markers of CD4 T cell recovery. In addition to measuring T cell activation and proliferation markers, CD4 T cell generation and ...
Abstract Background Chronic colonic inflammation in inflammatory bowel disease (IBD) patients increases the risk of colitis-associated cancer (CAC). Cancer development CAC is different from that observed sporadic colorectal (CRC). Most studies have focused on role pro-inflammatory immune cell subsets CAC, yet it becoming increasingly clear immunosuppression may also drive progression. We hypoth...
background: brucellosis is one of the most common chronic diseases, with widespread distribution. in spite of cell-mediated immunity (cmi) modulated mainly via activated t-helper type 1 (th1) cells, brucellosis can advance to chronic disease in about 10-30% of cases. regulatory t cells (treg cells) are involved the immune response to brucellosis; however, their role, particularly in the chang...
cytokine production in response to allergens may influence the development of atopy- predisposing immune responses, initializing the early programming of allergy and asthma. vitamin d intake may be protective due to its immunoregulatory properties, that may contribute to influence the expression of the atopic phenotype initiated in early life. the objective of our study was to ...
The parameters controlling the generation of robust CD4(+) T cell recall responses remain poorly defined. In this study, we compare recall responses by CD4(+) and CD8(+) memory T cells following rechallenge. Homologous rechallenge of mice immune to either lymphocytic choriomeningitis virus or Listeria monocytogenes results in robust CD8(+) T cell recall responses but poor boosting of CD4(+) T c...
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