نتایج جستجو برای: exosome activity

تعداد نتایج: 1137073  

Journal: :RNA 2008
Jannie Assenholt John Mouaikel Kasper R Andersen Ditlev E Brodersen Domenico Libri Torben Heick Jensen

Production of aberrant messenger ribonucleoprotein particles (mRNPs) is subject to quality control (QC). In yeast strains carrying mutations of the THO complex, transcription induction triggers a number of interconnected QC phenotypes: (1) rapid degradation of several mRNAs; (2) retention of a fraction of THO-dependent mRNAs in transcription site-associated foci; and (3) formation of a high mol...

2017
Yiran Wang Qijin Wang Xianzhao Wei Jie Shao Jian Zhao Zicheng Zhang Ziqiang Chen Yushu Bai Ning Wang Yajie Wang Ming Li Xiao Zhai

BACKGROUND Exosomes are small vesicles of endosomal origin, and they can be used for the diagnosis and the treatment. However, limited data were for the evaluation of the trend of exosome researches. This study aims to investigate the trend of exosome researches and compare the contribution of research from different regions, organizations and authors. METHODS Exosome related publications fro...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2017
Mengxi Wu Yingshi Ouyang Zeyu Wang Rui Zhang Po-Hsun Huang Chuyi Chen Hui Li Peng Li David Quinn Ming Dao Subra Suresh Yoel Sadovsky Tony Jun Huang

Exosomes are nanoscale extracellular vesicles that play an important role in many biological processes, including intercellular communications, antigen presentation, and the transport of proteins, RNA, and other molecules. Recently there has been significant interest in exosome-related fundamental research, seeking new exosome-based biomarkers for health monitoring and disease diagnoses. Here, ...

2018
Phimon Atsawasuwan Paul Lazari Yinghua Chen Xiaofeng Zhou Grace Viana Carla A Evans

Secretory microRNAs (miRNAs) have been used increasingly as biomarkers for cancers, autoimmune diseases and inflammatory diseases. They are reported as being freely circulated or encapsulated in microvesicles such as exosomes. This study was performed to elucidate the presence of miRNAs with exosomes in human gingival crevicular fluid (GCF), and the expression profile of miRNA-29 during orthodo...

2016
Fahimeh Shahabipour Maciej Banach Amirhossein Sahebkar

Exosomes are nano-sized vesicles that facilitate intercellular communications through carrying genetic materials and functional biomolecules. Owing to their unique size and structure, exosomes have emerged as a useful tool to overcome the limitations of siRNA delivery. The use of exosomes as siRNA delivery vehicles lacks certain disadvantages of the existing foreign delivery systems such as vir...

2007
Marina Cristodero Christine E. Clayton

The yeast putative RNA helicase Mtr4p is implicated in exosome-mediated RNA quality control in the nucleus, interacts with the exosome, and is found in the 'TRAMP' complex with a yeast nuclear poly(A) polymerase (Trf4p/Pap2p or Trf5p) and a putative RNA-binding protein, Air1p or Air2p. Depletion of the Trypanosoma brucei MTR4-like protein TbMTR4 caused growth arrest and defects in 5.8S rRNA pro...

Journal: :Bioimpacts 2023

Introduction: This study aimed to assess the potential of poly (acrylic acid)/tricalcium phosphate nanoparticles (PAA/triCaPNPs) scaffold in terms biocompatibility and osteoconductivity properties in-vivo evaluation as well investigate performance PAA/triCaPNPs (with or without exosomes derived from UC-MSCs) for bone regeneration rat critical-sized defect. Methods: was made acrylic acid (AA) mo...

Journal: :Molecular cancer research : MCR 2011
Rebecca A Silverstein Ernesto González de Valdivia Neus Visa

5-Fluorouracil (5FU) is a fluoropyrimidine used for the treatment of solid tumors. 5FU is a precursor of dTTP and UTP during biogenesis, and it interferes with both DNA and RNA metabolism. The RNA exosome, a multisubunit complex with ribonucleolytic activity, has been identified as one of the targets of 5FU in yeast. Studies in human cells have shown that the catalytic subunit of the nuclear ex...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2012
Huijue Jia Xuying Wang James T Anderson Eckhard Jankowsky

Many RNA-processing events in the cell nucleus involve the Trf4/Air2/Mtr4 polyadenylation (TRAMP) complex, which contains the poly(A) polymerase Trf4p, the Zn-knuckle protein Air2p, and the RNA helicase Mtr4p. TRAMP polyadenylates RNAs designated for processing by the nuclear exosome. In addition, TRAMP functions as an exosome cofactor during RNA degradation, and it has been speculated that thi...

Journal: :Journal of Drug Delivery Science and Technology 2022

Exosomes are a sub-group of extracellular vesicles, playing an important part in cell-cell communication many physiological and pathological conditions. Their size competence for transferring material to recipient cells make them promising nanocarrier clinical use. non-immunogenic nature, similar the body's own structure far superior transporters compared liposomes polymeric nanoparticles. This...

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