OBJECTIVE To prospectively characterize the relation between 1-year changes in neurologist ratings of abnormalities as measured by means of the Expanded Disability Status Scale (EDSS) and changes in observations of functional impairment as measured by means of the Multiple Sclerosis Functional Composite (MSFC) in the clinical assessment of multiple sclerosis (MS). METHODS One hundred twenty p...

patients and methods in this study, a total of 92 patients with relapsing-remitting multiple sclerosis (rrms) were randomly allocated into three equal groups; each treatment group received one of the foregoing drugs (cinnovexr, rebif and betaferon) for one year. at the beginning and end of the study, patients ‘ edss was measured and compared. results in this study, the relative frequency of fem...

OBJECTIVE The aim of this study was to assess the psychometric properties of the Multiple Sclerosis Impact Scale (MSIS-29) for patients in the community and in a hospital setting. METHODS During an epidemiological study, 172 people with multiple sclerosis (MS) were examined and completed the MSIS-29, the London Handicap Scale, and Beck's Depression Inventory; disability was assessed by the Ku...

This study investigates the application of classification methods for the prognosis of future disability on MRIdetectable brain white matter lesions in subjects diagnosed with clinical isolated syndrome (CIS) of multiple sclerosis (MS). In order to achieve these we had collected MS lesions from 38 subjects, manually segmented by an experienced MS neurologist, on transverse T2-weighted images ob...

BACKGROUND Gait disability in patients with secondary progressive multiple sclerosis (SPMS) or primary progressive multiple sclerosis (PPMS) rarely improves. PRIMARY STUDY OBJECTIVE This article reports on a case series of patients with SPMS and PPMS who were treated using neuromuscular electrical stimulation (NMES), a well-tolerated physical therapy (PT) treatment modality used to aid muscul...

OBJECTIVES To derive a simple predictive model to guide the use of corticosteroids in patients with relapsing remitting MS suffering an acute relapse. MATERIALS AND METHODS We analysed individual patient randomised controlled trial data (n=98) using a binary logistic regression model based on age, gender, baseline disability scores [physician-observed: expanded disability status scale (EDSS) ...

    Background: Dysphagia is frequently observed in patients with multiple sclerosis (MS). Dysphagia and its complications are common causes of morbidity and mortality in final stages of MS disease. This study aimed at determining the prevalence of dysphagia in Iranian patients with MS and identifying predictors associated with dysphagia.    Methods: A total of 230 MS ...

BACKGROUND Fatigue is a common symptom of multiple sclerosis patients that may be present at all stages of the disease. The aim of this study was to determine presence of fatigue in multiple sclerosis patients during relapse and its relation to neurological disability and depression. SUBJECTS AND METHODS This cross-sectional study included 120 patients who were assessed during the acute relap...

BACKGROUND The disease course in multiple sclerosis (MS) is influenced by many factors, including age, sex, and sex hormones. Little is known about sex-specific changes in disease course around age 50, which may represent a key biological transition period for reproductive aging. METHODS Male and female subjects with no prior chemotherapy exposure were selected from a prospective MS cohort to...