* Corresponding author. Chairman of the Accreditation Assessment Committee, Department of Cardiology, Hammersmith Hospitals NHS Trust at Charing Cross Hospital, Fulham Palace Road, London W6 8RF, UK. Tel.: C44 208 846 1917; fax: C44 208 746 8182. E-mail address: [email protected] (K.F. Fox). 1 The Accreditation Assessment Committee of the European Association of Echocardiography. 2 President...

Both T(H)1 and T(H)17 lymphocytes are implicated in inducing EAE. In mice lacking IFNgamma, T(H)17 are assumed to be the subset responsible for inflammation induction. Here, we demonstrate that IFNgamma KO mice have two additional effector subsets, one that up-regulates T(H)17-associated pro-inflammatory genes, but does not make IL-17 protein, and a second that utilizes IL-12-related elements o...

Here, we report the draft genome sequence of Escherichia coli strain R811. This bacterium was isolated from the bloody stool sample of a common marmoset, and was categorized as enteropathogenic E. coli because it possessed eae.

The decision to establish a major annual conference was the crucial step in our development from the Working Group on Echocardiography of the ESC, ultimately into the EAE, and the Euroecho meeting remains the jewel in our crown. In Florence last December we had a record attendance of almost 2900 participants from 82 countries, including a record number from industry. More abstracts than ever be...

multiple sclerosis (ms) and its animal model, experimental autoimmune encephalomyelitis (eae), are chronic inflammatory demyelinating disorders of central nervous system (cns). while the cause is unclear, the fundamental mechanism is thought to be destruction of myelin sheaths of neurons through immune system. one of the approaches being proposed in eae therapy is neural stem cells (nscs) trans...

myelinating disease of the central nervous system (CNS) that takes a relapsing–remitting or a progressive course (reviewed in Refs 1,2). Its counterpart in the peripheral nervous system (PNS) is chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) (reviewed in Ref. 3). In addition, there are acute, monophasic disorders, such as the inflammatory demyelinating polyradiculoneuropathy t...

Administration of peptide antigens in tolerogenic form holds promise as a specific treatment for autoimmune and allergic disorders. However, experiments in rodent autoimmune models have highlighted the risk of anaphylaxis in response to systemic peptide application once the aberrant immune response is underway. Thus, mice with clinical signs of experimental autoimmune encephalomyelitis (EAE) or...

BACKGROUND Regulatory T (Treg) cells can be induced with DNA vaccinations and protect mice from the development of experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis (MS). Tacrolimus (FK506) has been shown to have functions on inducing immunosuppression and augmenting apoptosis of pathologic T cells in autoimmune disease. Here we examined the therapeutic effect...

BACKGROUND Experimental autoimmune encephalomyelitis (EAE) is used as an animal model for human multiple sclerosis (MS), which is an inflammatory demyelinating autoimmune disease of the central nervous system characterized by activation of Th1 and/or Th17 cells. Human autoimmune diseases can be either exacerbated or suppressed by infectious agents. Recent studies have shown that regulatory T ce...

1 Department of Neurosciences, Centre de recherche du CHU de Québec – Université Laval, Quebec City, QC, Canada, 2 Department of Molecular Medicine, Université Laval, Quebec City, QC, Canada, 3 Department of Microbiology and Immunology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada, 4 Department of Neurosciences, Université de Montréal and CRCHUM, Montréal, Q...