RNA-binding proteins (RBPs) are essential for regulating RNA metabolism, stability, and translation within cells. Recent studies have shown that RBPs not restricted to intracellular functions can be found in extracellular vesicles (EVs) different mammalian EVs released by fungi contain a variety of involved metabolism. These include helicases, which play roles synthesis, folding, degradation. A...

transforming growth factor betas (tgf?s) are one of the most widespread and versatile cytokines. the three mammalian tgf? isoforms, ?1, ?2, and ?3, and their receptors regulate proliferation of neuronal precursors as well as survival and differentiation in neurons of developing and adult nervous system. functions of tgf?s has a wide spectrum ranging from regulating cell proliferation and differ...

background: parasite proteases have important roles in cleavage of host proteins during the invasion of host tissues and participate in the parasite’s evasion from the host’s immune response. the aim of the present study was to estimate a metalloproteinase properties of taenia solium metacestode (tsmp) during host-parasite interactions, and evaluate its potential as a serodiagnostic antigen for...

objective (s): the scarcity of articular cartilage defect to repair due to absence of blood vessels and tissue engineering is one of the promising approaches for cartilage regeneration. the objective of this study was to prepare an extracellular matrix derived decellularized bovine articular cartilage scaffold and investigate its interactions with seeded rat bone marrow mesenchymal stem cells (...

BACKGROUND Bacterial production of natively folded heterologous proteins by secretion to the extracellular space can improve protein production by simplifying purification and enabling continuous processing. In a typical bacterial protein production process, the protein of interest accumulates in the cytoplasm of the cell, requiring cellular lysis and extensive purification to separate the desi...

The phytopathogen Xylella fastidiosa causes economic losses in important agricultural crops. Xylem vessel occlusion caused by biofilm formation is the major mechanism underlying the pathogenicity of distinct strains of X. fastidiosa. Here, we provide a detailed in vitro characterization of the extracellular proteins of X. fastidiosa. Based on the results, we performed a comparison with a strain...

Helminth parasites secrete several types of biomolecules to ensure their entry and survival in hosts. The proteins secreted the extracellular environment participate pathogenesis anthelmintic immune responses. aim this work was identify functionally annotate excretory/secretory (ES) monogenean ectoparasite Rhabdosynochus viridisi through bioinformatic approaches. A total 1655 putative ES were i...

Abstract Histone deacetylases (HDAC) are enzymes that regulate the concentration of acetylated histones which, in turns, interact with bromodomain (BRD) BET (Bromodomain and Extracellular domain) proteins to affect transcriptional activity. Simultaneous blockade both epigenetic players has shown synergistic effects a variety cancer cell lines. In this paper we report design, synthesis activity ...