OBJECTIVE Extended release (XR) and immediate release (IR) quetiapine have differing dosing, titration and plasma concentration profiles. The authors assessed whether the use of quetiapine XR and IR in schizophrenia spectrum disorders (SCZ) and bipolar disorder (BD) differ. DESIGN Retrospective non-interventional registry study. SETTING Secondary healthcare. PARTICIPANTS All SCZ and BD (I...

Genetic and environmental factors are associated with psychosis risk, but the latter present more tangible markers for prevention. We conducted a theoretical exercise to estimate the proportion of psychotic illnesses that could be prevented if we could identify and remove all factors that lead to increased incidence associated with ethnic minority status and urbanicity. Measures of impact by po...

Corticotropin releasing factor (CRF) is a major mediator of central nervous system responses to stressors, including alterations in wakefulness and sleep. However, its role in mediating stress-induced alterations in sleep has not been fully delineated. In this study, we assessed the role of CRF and the non-specific CRF antagonist, astressin (AST), in regulating changes in sleep produced by sign...

Low-grade inflammation is a risk factor for depression, psychosis and other major psychiatric disorders. It is associated with poor response to antidepressant and antipsychotics, and could potentially be a treatment target. However, there is limited data on the prevalence of low-grade inflammation in major psychiatric disorders, and on the characteristics of patients who show evidence of inflam...

BACKGROUND Although the depth of the counting chamber is an important factor influencing sperm counting, no research has yet been reported on the measurement and comparison of the depth of the chamber. We measured the exact depths of six kinds of sperm counting chambers and evaluated their accuracy. MATERIALS AND METHODS In this prospective study, the depths of six kinds of sperm counting cha...

BACKGROUND Patients with psychoses have an increased risk of becoming victims of violence. Previous studies have suggested that higher symptom levels are associated with a raised risk of becoming a victim of physical violence. There has been, however, no evidence on the type of symptoms that are linked with an increased risk of recent victimization. METHODS Data was taken from two studies on ...

Aims The audit was undertaken to explore if inpatients with treatment resistant schizophrenia (TRS), or whose condition has not adequately responded two antipsychotics of an optimal duration and dose, were offered clozapine as per NICE guidelines (CG178 1.5.7.2). Methods Data collected retrospectively anonymously from all electronic notes via the UK-CRIS analysis platform. inclusion criteria re...

Aims To determine potentially significant drug interactions in an old age setting among inpatients with psychosis and medical comorbidities over the past 12 months Methods Study setting: inpatient functional ward Sample size: 11 Inclusion criteria: • Inpatients on psychotropic medications diagnosis ranging from F20 to F29 (ICD-10) Comorbid chronic condition(s) requiring long term treatment Excl...

Abstract Background Psychotic major depression (PMD) is a subtype of with poor prognosis. Previous studies have failed to find many differences between patients PMD and those non-psychotic (NMD) or schizophrenia (SZ). We compared sociodemographic factors (including season conception) clinical characteristics PMD, NMD, schizophrenia. Our aim was provide data help inform diagnoses future etiology...

Background Although the depth of the counting chamber is an important factor influencing sperm counting, no research has yet been reported on the measurement and comparison of the depth of the chamber. We measured the exact depths of six kinds of sperm counting chambers and evaluated their accuracy. MaterialsAndMethods In this prospective study, the depths of six kinds of sperm counting chamber...