A noncytotoxic protein substance, produced by Streptococcus intermedius, with very potent immunosuppressive properties (F3'EP-Si) was tested for lymphocyte mitogenic activity. Although devoid of T-cell mitogenicity, F3'EP-Si stimulated proliferation and led to high numbers of plaque-forming cells in cultures of normal or T-cell-depleted, small or large splenic B cells from both lipopolysacchari...

In this paper we study the homotopical rotation vectors and the homotopical rotation sets for the billiard flow on the unit flat torus with three, mutually intersecting and mutually orthogonal cylindrical scatterers removed from it. The natural habitat for these objects is the infinite cone erected upon the Cantor set Ends(F3) of all “ends” of the hyperbolic group F3 = π1(Q). An element of Ends...

This study investigated fluoride release, acid resistance and shear bond strength (SBS) of new 4-META/MMA-TBB-based fluoride-containing resin adhesive (Super-Bond/F3). Super-Bond, Transbond Plus and Fuji Ortho LC were selected for comparison. Fluoride release into distilled water during 6-month period was measured using disk-shaped specimens. Brackets were bonded to human premolars with each ma...

The perception of the distinction between /r/ and /l/ by native speakers of American English and of Japanese was studied using natural and synthetic speech. The American subjects were all nearly perfect at recognizing the natural speech sounds, whereas there was substantial variation among the Japanese subjects in their accuracy of recognizing /r/ and /l/ except in syllable-final position. A lo...

House dust mites (HDM) are most important indoor allergens for humans. Der f3, one of the potent allergens with allergenicity, is derived from Dermatophagoides farina (D. farinae), and exhibits strong allergenicity that was confirmed in our previous work. The current study was undertaken to determine the localization of T-cell epitope of Der f3. We initially developed the T-cell fraction from B...

Amyotrophic lateral sclerosis (ALS) is the most common adult onset motor neuron disease. The etiology and pathogenic mechanisms of the disease remain unknown, and there is no effective treatment. Here we show that intrathecal transplantation of human motor neurons derived from neural stem cells (NSCs) in spinal cord of the SOD1G93A mouse ALS model delayed disease onset and extended life span of...

PURPOSE To characterize the fundamental frequency and the frequency of the formants F1, F2, F3, and F4 from vocal emissions of amateur singers with metallic voice quality. METHODS There were 60 amateur female singers aged between 18 and 60 years old; 30 women with metallic voice quality forming the study group (SG) and 30 women without such a vocal quality forming control group (CG). The samp...

OBJECTIVE This study evaluated apical transportation associated with ProTaper Universal Fl, F2 and F3 rotary files in curved canais prepared by undergraduate students. MATERIAL AND METHODS Twenty mesial roots of mandibular molars with curvatures ranging between 25° and 35° were selected. Mesiobuccal canals were instrumented by twenty students with the ProTaper system (Dentsply-Maillefer, Ball...

on transcriptional activation by serum response factor. A truncated form of the type II TGF-j3 receptor, created by deletion of the cytoplasmic kinase domain, acts as a dominant suppressor of TGF-f3 signal transduction in cultured cardiac muscle cells and may provide a suitable means to establish the functions of TGF-f3 in vivo. (Circ Res. 1993;73:783-791.)