We present a general theory to study optimal regularity for a large class of nonlinear elliptic systems satisfying general boundary conditions and in the presence of a geometric transmission condition on the free-boundary. As an application we give a full positive answer to a conjecture of De Giorgi on the analyticity of local minimizers of the Mumford-Shah functional.

Acute lung injury (ALI) is a devastating syndrome (usually associated with sepsis) that represents a major healthcare burden in the United States. We have focused our studies on unraveling the genetic underpinnings of this syndrome utilizing a candidate gene approach to identify novel genes for ALI susceptibility. Two novel genes identified by this approach include pre-B cell colony-enhancing f...

Department of Oral & Maxillofacial Surgery, Sharavathi Dental College and Hospital, Shimoga, Karnataka, India Department of Periodontics, K.M. Shah Dental College and Hospital, Sumandeep Vidyapeeth, Vadodara, Gujarat, India Department of Oral Medicine & Radiology, Sharavathi Dental College and Hospital, Shimoga, Karnataka, India Department of Conservative and Endodontics, K.M Shah Dental Colleg...

Early recognition of patients at high risk of acute lung injury (ALI) is critical for successful enrollment of patients in prevention strategies for this devastating syndrome. We aimed to develop and prospectively validate an ALI prediction score in a population-based sample of patients at risk. In a retrospective derivation cohort, predisposing conditions for ALI were identified at the time of...

Acute lung injury (ALI) during hematopoietic stem cell transplant (HSCT) is associated with substantial morbidity; however, the frequency of ALI in HSCT patients is poorly characterized. Platelets are postulated to play a critical role in the pathogenesis of ALI. Using a transfusion trial of pathogen inactivated platelet components (PC-Test) compared with conventional PC (Reference) populated w...

Su X, Looney MR, Gupta N, Matthay MA. Receptor for advanced glycation end-products (RAGE) is an indicator of direct lung injury in models of experimental lung injury. Am J Physiol Lung Cell Mol Physiol 297: L1–L5, 2009. First published May 1, 2009; doi:10.1152/ajplung.90546.2008.—Receptor for advanced glycation end-products (RAGE) is a marker of alveolar type I cells and is elevated in the pulm...

BACKGROUND Few emergency department (ED) evaluations on acute lung injury (ALI) have been carried out; hence, we sought to describe a cohort of hospitalized ED patients at risk for ALI development. METHODS Patients presenting to the ED with at least one predisposing condition to ALI were included in this study, a subgroup analysis of a multicenter observational cohort study (USCIITG-LIPS 1). ...