PURPOSE/OBJECTIVES To examine the patterns of fatigue, physical activity, health status, and quality of life before and after high-dose chemotherapy and hematopoietic stem cell transplantation (HSCT) and to examine the feasibility of obtaining real-time fatigue and physical activity data. DESIGN Prospective, repeated measures. SETTING Two midwestern academic medical centers. SAMPLE Conven...

INTRODUCTION Cancer-related fatigue greatly influences quality of life in cancer patients; however, no specific treatments have been established for cancer-related fatigue, and at present, no medication has been approved in Japan. Systematic research using patient-reported outcome to examine symptoms, particularly fatigue, has not been conducted in palliative care settings in Japan. The objecti...

BACKGROUND Adolescents with cancer experience distressing physical and psychosocial symptoms, especially during treatment. Fatigue and sleep disturbances commonly affect adolescents' quality of life, but little is known about how adolescents experience these symptoms during an early month of chemotherapy. This study measured fatigue, sleep disturbances, and quality of life in 20 adolescents ove...

Successful arrest and retardation of fatigue cracks is achieved with an in situ self-healing epoxy matrix composite that incorporates microencapsulated dicyclopentadiene (DCPD) healing agent and Grubbs first generation Ru catalyst. Healing agent is released into the crack plane by the propagating crack, where it polymerizes to form a polymer wedge, generating a crack tip shielding mechanism. Du...

UNLABELLED Fatigue is a significant symptom in multiple sclerosis (MS) patients. First-generation disease modifying therapies (DMTs) are at best moderately effective to improve fatigue. Observations from small cohorts have indicated that natalizumab, an antibody targeting VLA-4, may reduce MS-related fatigue. The TYNERGY study aimed to further evaluate the effects of natalizumab treatment on MS...

The non-linear nature of the superelastic phase transformation in NiTi means that conventional fatigue life theory is difficult to apply. The volume fraction of martensite/parent phase and its role in the fatigue mechanism is not understood. This paper considers the fatigue life of superelastic NiTi alloys when tested at 2Hz in Ringers solution. In agreement with other researchers [1] [2] it wa...

background: fatigue is considered as a major problem in hemodialysis patients and can impair their quality of life. the purpose of this study was to investigate the effectiveness of acupressure on fatigue in hemodialysis patients. materials and methods: this is a clinical trial study in which 96 hemodialysis patients participated. patients were randomly assigned into acupressure, placebo, and c...

BACKGROUND Calcification is commonly believed to be associated with cardiovascular disease burden. But whether or not the calcifications have a negative effect on plaque vulnerability is still under debate. METHODS AND RESULTS Fatigue rupture analysis and the fatigue life were used to evaluate the rupture risk. An idealized baseline model containing no calcification was first built. Based on ...

AIM OF THE STUDY To study if the use of a cooling-suit by individuals with multiple sclerosis (MS) influenced their experience of fatigue and consequent restrictions in daily life. BACKGROUND The majority of MS patients consider fatigue as one of their most disabling symptoms and as having a significant impact on their daily lives. Fatigue often increases in a warm environment. A cooling-suit...

This paper describes a finite element based method for simulating the effects of material removal, associated with fretting wear, on fretting fatigue parameters in a spline coupling. An incremental wear simulation technique is implemented with a single tooth finite element model of the coupling for symmetric loading, assuming equal wear on all teeth, using a comparatively coarse mesh model, for...