Epidemiologic studies of dietary marine n-3 fatty acids and risk of colorectal cancer have been inconsistent, and their relation to risk of colorectal adenoma has not been evaluated in detail. We examined dietary marine n-3 fatty acids and the ratio of marine n-3 to total n-6 fatty acids (n-3/n-6 ratio) in relation to risk of adenoma of the distal colon or rectum among 34,451 U.S. women who wer...

The Center for Genetics, Nutrition and Health, 2001 S Street, NW, Suite 530, Washington DC 20009 USA Abstract: Today, Western diets are characterized by a higher omega-6 and a lower omega-3 fatty acid intake, whereas during the Paleolithic period when human’s genetic profile was established, there was a balance between omega-6 and omega-3 fatty acids. Their balance is an...

BACKGROUND Fatty acids are substantial components of lipids and cell membranes in the form of phospholipids. This review consists of two parts. The present part aims at describing fatty acid classification, dietary sources and biological functions. The second part will focus on fatty acid physiological roles and applications in human health and disease. RESULTS In humans, not all fatty acids ...

Few EU countries meet targets for saturated fatty acid (SFA) intake. Dairy products usually represent the single largest source of SFA, yet evidence indicates that milk has cardioprotective properties. Options for replacing some of the SFA in milk fat with cis-monounsaturated fatty acids (MUFA) through alteration of the cow's diet are examined. Also, few people achieve minimum recommended intak...

OBJECTIVE To review the various biomarkers of dietary intakes of fatty adds in human populations, their measurement, limitations and analytical considerations. DESIGN Review of the literature. RESULTS Although there is no good biomarker of intake of total fat, a number of alternatives exist for assessing the intakes of exogenously produced fatty acids that are consumed. Adipose tissue, eryt...

The procedures implemented in the production of functional foods of animal origin should be based on the scientifically verified new knowledge comprising the entire food chain. Possible physiological and psychological effects of such foods on humans should not be neglected. Although the human genome did not change since the Palaeolithic, however the nutritional habits and way of life of modern ...

undergo terminal catabolism in these cells. Controversy Advances in Vascular Biology—Volume 5: is continuing as to whether the amount of total dietary Plasma Lipids and Their Role in Disease fatty acids or only that of saturated fatty acids should Edited by Philip J. Barter be reduced. Also, plasma lipids are affected differently and Kerry-Anne Rye by n-6 as opposed to n-3 polyunsaturated fatty...

The present study was conducted to evaluate the effects of using raw or microwave irradiated safflower seed on dry matter intake, milk production and composition, milk fatty acid profile, blood parameters, and nutrient apparent digestibility in early lactation cows. Nine multiparous Holstein cows at early lactation were randomly assigned to one of three treatments based on 3 × 3 balanced latin ...

The modification of dietary patterns has led to a change in fatty acid consumption, with an increase in the consumption of ω-6 fatty acids and a marked reduction in the consumption of ω-3 fatty acids. This in turn has given rise to an imbalance in the ω-6/ω-3 ratio, which is now very different from the original 1:1 ratio of humans in the past. Given the involvement of ω-6 and ω-3 essential fatt...

During the last century much evidence has accumulated to suggest that from a public health perspective the type of fat is more important than the amount of fat. Saturated and trans-fatty acids increase and both n-6 and n-3 PUFA decrease the risk of CHD. Most of the knowledge about the effects of dietary fatty acids on CHD risk is based on observational studies and controlled dietary experiments...