This paper proposes a combined canonical variate analysis (CVA) and Fisher discriminant analysis (FDA) scheme (denoted as CVA–FDA) for fault diagnosis, which employs CVA for pretreating the data and subsequently utilizes FDA for fault classification. In addition to the improved handling of serial correlations in the data, the utilization of CVA in the first step provides similar or reduced dime...

INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1004 R I. AN INTRODUCTORY WORD, MAINLY CONCERNING SCOPE . . . 1004 R II. FDA REGULATION’S ORIGINS AND DEVELOPMENT. . . . . . . . . . 1007 R III. ANALYSIS OF REGULATORY COMPLIANCE’S RELEVANCE. . . . . . 1010 R A. The Relevance Traditionally Accorded Regulatory Compliance . . . . . . . ....

this commentary explores the implications of increased social media marketing by drug manufacturers, based on findings in hyosun kim’s article of the major themes in recent food and drug administration (fda) warning letters and notices of violation regarding online direct-to-consumer promotions of pharmaceuticals. kim’s rigorous analysis of fda letters over a 10-year span highlights a relative ...

We investigated the effect of a candidate artificial blood substitute, Fluosol-DA (FDA), on human neutrophil function in a serum-free medium. In a 50% (vol/vol) mixture with polymorphonuclear cells (PMN), FDA had no effect on PMN viability, phagocytosis, superoxide anion generation, degranulation, or bactericidal activity. In striking contrast, the random migration and chemotaxis of PMN to both...

Introduction C ancer is the second leading cause of death in the United States, exceeded only by heart disease, and it is the leading cause of death among those 35 to 64 years of age. One of every four deaths is from cancer. The federal government has spent more than $46 billion on cancer research since President Nixon declared a War on Cancer and Congress passed the National Cancer Act in 1971...