Non-heme iron and manganese species with terminal oxo ligands are proposed to be key intermediates in a variety of biological and synthetic systems; however, the stabilization of these types of complexes has proven difficult because of the tendency to form oxo-bridged complexes. Described herein are the design, isolation, and properties for a series of mononuclear Fe(III) and Mn(III) complexes ...

BACKGROUND The present study evaluated whether magnetic nanoparticles containing Fe(3)O(4) could enhance the activity of gambogic acid in human colon cancer cells, and explored the potential mechanisms involved. METHODS Cytotoxicity was evaluated by MTT assay. The percentage of cells undergoing apoptosis was analyzed by flow cytometry, and cell morphology was observed under both an optical mi...

Reaction pathways for the one- and two-electron reductions of [Fe(CN)(5)NO](2)(-) have been investigated by means of a density functional theory (DFT) approach combined with the polarized continuum model (PCM) of solvation. In addition, UV-vis spectroscopic data were obtained using ZINDO/S calculations including a point-charge model simulation of solvent effects. DFT methodologies have been use...

The substitution reactions of the tetrahedral Fe sites in [FeCl(4)](-), [Fe(2)S(2)Cl(4)](2-), [Fe(4)S(4)Cl(4)](2-) and [{MoFe(3)S(4)Cl(3)}(2)(micro-SEt)(3)](3-) with 4-RC(6)H(4)S(-) (R = MeO, Me, H, Cl or NO(2)) all involve rapid binding of the thiolate to a Fe site and formation of a kinetically and spectroscopically detectable intermediate. Kinetic studies allow calculation of the rate of Fe-...

The reaction of [Fe(II)(tris(2-pyridylmethyl)amine, TPA)(NCCH(3))(2)](2+) with 1 equiv. peracetic acid in CH(3)CN at -40 degrees C results in the nearly quantitative formation of a pale green intermediate with lambda(max) at 724 nm ( epsilon approximately 300 M(-1).cm(-1)) formulated as [Fe(IV)(O)(TPA)](2+) by a combination of spectroscopic techniques. Its electrospray mass spectrum shows a pro...

A novel class of water-soluble iron nitrosyl complexes has been developed for use as NO donor prodrugs. To elaborate these NO prodrugs various water-soluble ligands were used such as P(CH2OH)3, 1,3,5-triaza-7-phosphatricyclo[3.3.1.1]decane (PTA), 1,2-bis[bis(hydroxymethyl)phosphino]ethane (HMPE), 1,2-bis[bis(hydroxymethyl)phosphino]benzene (TMBz), cysteamine, cysteamine hydrochloride, L-cystein...

In the title compound, [Fe(C(6)H(4)NO(3))(C(7)H(3)NO(4))(H(2)O)]·H(2)O, the Fe(III) ion is coordinated by two O and one N atoms from a pyridine-2,6-dicarboxyl-ate ligand, by two O atoms from a picolinate N-oxide ligand and by one water O atom in a distorted octa-hedral geometry [Fe-O = 1.940 (3)-2.033 (3) Å and Fe-N = 2.057 (4) Å]. In the crystal structure, the coordinated and solvent water mol...

A novel heterostructure is developed by grafting 1D SnO(2) nanorods onto both sides of pre-grown 2D Fe(2)O(3) nanoflakes, forming a comb-like rather than tree-like branched nanostructure. The SnO(2) nanorod branches are determined to grow along the [001] direction on the (±001) planes of Fe(2)O(3) nanoflakes. The resulting SnO(2)@Fe(2)O(3) nanocombs show stabilized cycling performance and impro...

OBJECTIVES The Burkholderia cepacia complex is a group of pathogens that can cause severe pulmonary infections in cystic fibrosis (CF) patients. The aim of the present study was to investigate the in vitro activity of gallium against planktonic and biofilm-grown B. cepacia complex isolates. METHODS Six B. cepacia complex isolates (belonging to three different species) as well as Pseudomonas a...

This study describes the O2 reactivity of a series of high-spin mononuclear Fe(II) complexes each containing the facially coordinating tris(4,5-diphenyl-1-methylimidazol-2-yl)phosphine ((Ph2)TIP) ligand and one of the following bidentate, redox-active ligands: 4-tert-butylcatecholate ((tBu)CatH(-)), 4,6-di-tert-butyl-2-aminophenolate ((tBu2)APH(-)), or 4-tert-butyl-1,2-phenylenediamine ((tBu)PD...