BACKGROUND & OBJECTIVE Analysis of the microdeletions in the azoospermia factor (AZF) region of Y chromosome by PCR is an important screening tool in the work-up of infertile males opting for assisted reproductive techniques. In the present study, the Y chromosome microdeletions were analyzed by PCR using primers corresponding to 16 sequence tagged sites (STS) and three genes of the AZF region ...

background: it is established that sperm dna integrity is essential in fertilization and normal embryo and fetal development. routine semen analysis gives an approximate evaluation of the functional competence of spermatozoa, but does not always reflect the quality of sperm dna. therefore, the evaluation of sperm dna integrity, in addition to routine sperm parameters, could add further informat...

The DAZ gene, a contributing factor in infertility, lies on the human Y chromosome's AZFc region, whose deletion is a common cause of spermatogenic failure. Y chromosome binary polymorphisms on the non-recombining Y (NRY) region, believed to be a single occurrence on an evolutionary scale, were typed in a sample of fertile and infertile men with known DAZ backgrounds. The Y single-nucleotide po...

background: sexual problems have different effects on the life of people by influencing their interpersonal and marital relationships and satisfaction. relationship between sexual dysfunctions and infertility can be mutual. sexual dysfunction may cause difficulty conceiving but also attempts to conceive, may cause sexual dysfunction. objective: this paper compares sexual dysfunction in fertile ...

In this issue ofHumanReproduction, Augeret al. (2016) examine sperm abnormalities in fertile and infertile men, and those with testicular cancer, extendingwhatwas published in themost recent version of theWHOLaboratory Manual for the Examination and Processing of Human Semen (WorldHealthOrganization, 2010) onnormal sperm forms.That publicationattempted for thefirst timetoraise thequalityof seme...

Factors affecting the blood-testis barrier function may be involved in testicular damage and male infertility. Two cytokines play an important role in the barrier regulation, namely transforming growth factor beta 3 (TGF-β3) and tumor necrosis factor (TNF-α). The aim of this study was to investigate the potential association between TGF-β3 (TGFB3) and TNF-α (TNF) gene polymorphisms and male inf...

BACKGROUND Infertility is a severely distressing experience for many couples. Depression is considered as one of the main psychological disorders associated with infertility and it may significantly affect the life of infertile individuals, their treatment, and follow-up. OBJECTIVE The objective of the study was to determining the prevalence and predisposing factors of depressive disorders am...

BACKGROUND This article analyzes several key issues in the debate: the acceptability of in vitro fertilization; regulation of assisted reproduction and the possibilities of reimbursement for assisted reproduction treatment in Lithuania. METHOD Two groups of respondents participated in the survey: fertile women and women with fertility disorders. 93 completed questionnaires from women with fer...

Several studies have reported a relationship between the length of the CAG-repeat in the polymerase γ (POLG) gene and male infertility. However, other studies have not reproduced this result. In our study, the POLG-CAG-repeat length was analyzed in 535 healthy individuals from six Chinese Han populations living in different provinces. The frequencies of 10-CAG alleles and genotypes were high (9...