Not Be Used to Treat Diabetic Pregnant Women S tudies in pregnancy indicate that the most important glucose concentration throughout the day is the peak postprandial glucose response; i.e., it is the highest blood glucose of the day, not the average, that predicts risk of untoward effects. The Diabetes in Early Pregnancy (DIEP) Study was a multicenter, casecontrolled trial of type 1 diabetic wo...

INTRODUCTION The prevalence of obesity is increasing in both developed and developing nations. Body mass index (BMI) is the most common index for obesity assessment and its relation with most complications among non-pregnant and pregnant women is known. However, no study has evaluated the relation between abdominal obesity and macrosomia among pregnant women. METHODS In this prospective study...

background: due to increase in pregnancy complications in advanced age, this study was conducted to assess the relationship between advanced maternal age and the pregnancy complications. methods: pregnant women who admitted to the motazedi hospital in kermanshah were included in this analytic–cross sectional study. the study group was 1178 cases that divided into two sub-groups; 35-40 year-old ...

Tissue hypoxia is the major stimulus of erythropoietin (EPO) synthesis in fetuses and adults. Since EPO does not cross the placenta and is not stored, fetal plasma and amniotic fluid levels indicate EPO synthesis and elimination. Acutely, the rate and magnitude of the increase in plasma EPO levels correlate with the intensity of hypoxia. Amniotic fluid EPO levels correlate with cord plasma leve...

The adverse outcomes on the offspring from maternal diabetes in pregnancy are substantially documented. In this paper, we report main knowledge on impacts of maternal diabetes on early and long-term health of the offspring, with specific comments on maternal obesity. The main adverse outcome on progenies from pregnancy complicated with maternal diabetes appears to be macrosomia, as it is common...

OBJECTIVE Macrosomia is one of the most common complications in gestational diabetes mellitus. Insulin-like growth factor 2 and H19 are two of the imprinted candidate genes that are involved in fetal growth and development. Change in methylation at differentially methylated region of the insulin-like growth factor 2 and H19 has been proved to be an early event related to the programming of meta...

BACKGROUND As women increasingly delay child bearing, the proportion of women having their first delivery at ''advanced maternal age'' is expected to rise. These elderly primigravidae have traditionally been considered to be at increased risk of adverse maternal and perinatal outcomes because of associated pregnancy and labor complications and, therefore, need to be evaluated. AIM To determin...

I t is recognized that women with gestational diabetes mellitus (GDM) who have significantly elevated fasting blood glucose levels are at increased risk for fetal macrosomia and perinatal morbidity if treatment is not provided (1,2). The association of milder forms of GDM with perinatal morbidity and mortality remains unclear, primarily because the condition is often confounded with other risk ...