The aim of this work was to investigate the effects of the nature and concentration of cellulose derivatives on the release kinetics of ibuprofen from hydrogel matrices using a response surface method (RSM). A series of cellulose derivatives, as methyl, hydroxyethyl, hydroxypropyl and hydroxypropyl methyl celluloses (MC, HEC, HPC and HPMC) were used as polymer platforms and their impacts on dru...

Abstract With a view toward the application of highly hygroscopic polymers as humidity responsive self-actuator, evaluation real time moisture concentration in material becomes priority. In this paper, diffusion process cellulose acetate (53.3% acetylation) has been studied. Membranes (thickness within range 66–200 µm) have prepared, and absorption at room temperature different relative (RH 21–...

Transdermal drug delivery systems are polymeric patches containing dissolved or dispersed drugs that deliver therapeutic agents at a constant rate to the human body. Matrix type transdermal patches were prepared using alprazolam as a model drug and employing the combinations of chitosan-polyvinyl alcohol (CS-PVA) cross linked with Maleic anhydride. The transdermal patches were evaluated for the...

The present study was aimed to develop and evaluate nanoparticulate containing pioglitazone HCl as potential antidiabetic drug delivery system. The pioglitazone HCl -loaded chitosan nanoparticles were prepared by ionic gelation of chitosan with tripolyphosphate anions at various concentrations. The nanoparticles were characterized by zeta potential analyzer; particle size analyzer and Fourier t...

Kalman filtering is introduced as a rational means for developing a monitoring strategy for concrete structures. The mathematics and utility of linear Kalman filters are presented briefly, and the use of linear filters is demonstrated for Fickian diffusion. The nonlinear extended Kalman filter is introduced and its utility in estimating a transport parameter is demonstrated. The concrete servic...

The purpose of this study is to fabricate the polyethylene glycol matrix tablet by mold technique. Indomethacin and hydroxypropylmethylcellulose were used as model drug and polymer, respectively, in PEG matrix system. The physical and drug release characteristics of developed matrix tablet were studied. This inert carrier system comprising 7:3 polyethylene glycol 4000: polyethylene glycol 400 c...

Degradable, bioceramic bone implants made of calcium polyphosphate (CPP) hold potential for controlled release of therapeutic agents in the treatment of localized bone disease. Magnetic resonance imaging techniques for non-invasively mapping fluid distribution, T(1) and T(2) relaxation times and the apparent diffusion coefficient were performed in conjunction with a drug elution protocol to res...

In this contribution, we theoretically investigate the isothermal mass transport of a simple fluid into a blend of two immiscible Newtonian polymers. Using internal state variables, we derive a nonlinear formulation that addresses the effects of the diffusion/interface coupling on both the mass transport as well as on the morphology of the interface. The approach uses a scalar and a second-orde...

Accumulated experimental information is used to assess the possible significance of thermal diffusion to mass transport in living matter. Possible thermal gradients across membranes, a single living cell, and an ensemble of such cells (e.g. an organ, tumor, etc.) are estimated. The corresponding model calculations, although not describing the biological process in detail, lead to conclusions ab...

The moisture diffusion behaviors of 3D woven composites exhibit non-Fickian properties when they are exposed to a hydrothermal environment. Although some experimental works have been undertaken investigate this phenomenon, very few mathematical on predictions available in the literature. To capture behavior composites, study first utilized time fractional equation derive percentage content homo...