PURPOSE Relatively little data exist regarding the outcomes of children with primary infantile glaucoma presenting with acute corneal hydrops. The aim of our study was to determine the surgical outcome of children of infantile glaucoma who presented with acute corneal hydrops. METHODS In total, 38 eyes of 31 consecutive children of infantile glaucoma presented with acute corneal hydrops who u...

OBJECTIVE To examine the effect of cataract extraction (CE) after trabeculectomy on intraocular pressure (IOP) control. DESIGN Retrospective noncomparative case series. PARTICIPANTS A total of 115 consecutive patients who underwent extracapsular CE (N = 58) or phacoemulsification (N = 57) with intraocular lens (IOL) placement after trabeculectomy were studied. INTERVENTION Cataract extrac...

OBJECTIVE To determine concentrations of ofloxacin and ciprofloxacin hydrochloride in aqueous humor after topical or combined topical and oral administration in eyes with filtering blebs. DESIGN A prospective, investigator-masked, randomized, controlled comparative study involving 36 eyes of 34 patients with functioning filtering blebs who were to undergo cataract surgery. Treatment groups re...

PURPOSE . To determine the role of extracellular matrix (ECM), transforming growth factor β (TGF-β) and metalloproteinase 9 (MMP-9) in mechanisms filtering bleb formation after non-penetrating deep sclerectomy (NPDS) patients with primary open-angle glaucoma (POAG). METHODS The study consisted prospective examination 65 POAG operated by NPDS method. Three groups were formed: group 1 — optimal h...

PURPOSE This study aimed to propose the role of amniotic membrane transplantation (AMT) as an additional modulator in primary Mitomycin C (MMC)-augmented trabeculectomy. METHODS This was a randomized prospective interventional study. Forty eyes of 39 adult patients with uncontrolled primary glaucoma were randomly divided into two equal groups. Control group underwent trabeculectomy augmented ...

PURPOSE We used three-dimensional anterior-segment optical coherence tomography (3D AS-OCT) to evaluate time-dependent posttrabeculectomy changes in bleb wall volume and intensity. METHODS This prospective observational study included patients with open-angle glaucoma who underwent fornix-based trabeculectomy between January 2012 and October 2012. Twenty-nine eyes met inclusion criteria, and ...

15 Within the confines of tissues, cancer cells can use blebs to migrate. Eps8 is an actin bundling and 16 capping protein whose capping activity is inhibited by Erk, a key MAP kinase that is activated by 17 oncogenic signaling. We tested the hypothesis that Eps8 acts as an Erk effector to modulate actin 18 cortex mechanics and thereby mediate bleb-based migration of cancer cells. Cells confine...

The authors evaluated the effects of biodegradable poly (lactic acid) microspheres that provided the controlled release of the antimetabolic agent adriamycin (ADR) to prevent post surgical fibrosis after glaucoma filtering surgery. Fifty six eyes of 28 rabbits underwent posterior lip sclerotomy and received a 0.2 ml subconjunctival injection that contained microspheres 90 degrees from the filte...

BACKGROUND/AIMS To compare the penetration of levofloxacin, ofloxacin and ciprofloxacin in the aqueous humour of eyes with functioning filtering blebs. METHODS In this investigator-masked study, 48 patients with functioning filtering blebs requiring cataract surgery were randomised into six groups of eight patients. Groups 1, 2 and 3 received topical ofloxacin 0.3% (Ocuflox), ciprofloxacin 0....