Since the discovery of penicillin, antibiotics have been of critical importance in the control of infectious diseases. However, the extensive use and misuse of antibiotics during recent decades led to the widespread development and distribution of resistance to multiple drugs among bacteria. With the alarming levels of antibiotic resistance and the difficulties associated with discovering novel...

Matrix metalloproteinase (MMP)-9 degrades type IV collagen in the basement membrane and plays crucial roles in several pathological implications, including tumorigenesis and inflammation. In this study, we analyzed the effect of flavonols on MMP-9 expression in phorbol-12-myristate-13-acetate (PMA)-induced human fibrosarcoma HT-1080 cells. Galangin and kaempferol efficiently decreased MMP-9 sec...