In order to increase the bioavailability of poorly soluble drug as well as highly soluble drug, the residence time of the orally administered dosage form in the upper GIT needs to be prolonged. Gelucire are used as carrier for designing low density floating drug delivery system. Glibenclamide is a low dose, poorly soluble drug with possible content uniformity problems and dissolution rate-limit...

several plant extracts and phytoconstituents, despite having excellent bioactivity in vitro, demonstrate less or no in vivo actions due to their poor lipid solubility or improper molecular size or destruction in gut. drug delivery system for polyphenolic phytoconstituents (phytosomes) was prepared by complexing polyphenolic phytoconstituents with phospholipid mainly phosphatidylcholine which bi...

The oral delivery of drugs having narrow absorption window in the gastro-intestinal tract is limited by poor bioavailability with conventional dosage forms due to incomplete drug release and short residence time at the time of absorption. To provide controlled delivery of drugs novel drug delivery systems have been developed. Different systems have been developed to increase the gastric residen...

Aim: This research work was aimed to evaluate Metformin hydrochloride (MH) floating dosage form by In vitro evaluation/In vivo prediction and it’s predictability through application during the R&D using Insilico technique in WINONLIN Software. MH examined as a model drug, which is biguanide an hypoglycemic agent administered orally. The study determine systemic concentrations of In-vivo pre...

Drugs that have narrow absorption window in the gastro-intestinal tract (GIT) will have poor absorption. For these drugs, gastro-retentive drug delivery systems offer the advantages in prolonging the gastric emptying time. Floating and sustained release tablets are developed by using a combination of hydrophilic polymer (Hydroxypropyl methylcellulose) and effervescent substance (Sodium bicarbon...